Literature DB >> 18832128

Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.

Silke Besier1, Johannes Zander, Ekkehard Siegel, Stephan H Saum, Klaus-Peter Hunfeld, Annabelle Ehrhart, Volker Brade, Thomas A Wichelhaus.   

Abstract

We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

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Year:  2008        PMID： 18832128      PMCID： PMC2576584          DOI： 10.1128/JCM.01440-08

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  23 in total

1.  Clonal heterogeneity, distribution, and pathogenicity of methicillin-resistant Staphylococcus aureus.

Authors:  T A Wichelhaus; J Schulze; K P Hunfeld; V Schäfer; V Brade
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-12       Impact factor: 3.267

2.  Bloodstream infections caused by small-colony variants of coagulase-negative staphylococci following pacemaker implantation.

Authors:  C von Eiff; P Vaudaux; B C Kahl; D Lew; S Emler; A Schmidt; G Peters; R A Proctor
Journal:  Clin Infect Dis       Date:  1999-10       Impact factor: 9.079

3.  Radioimmunoassays of plasma thymidine, uridine, deoxyuridine, and cytidine/deoxycytidine.

Authors:  N P Dudman; W B Deveski; M H Tattersall
Journal:  Anal Biochem       Date:  1981-08       Impact factor: 3.365

4.  Altered thymidine metabolism due to defects of thymidine phosphorylase.

Authors:  Antonella Spinazzola; Ramon Marti; Ichizo Nishino; Antonio L Andreu; Ali Naini; Saba Tadesse; Ivana Pela; Enrico Zammarchi; M Alice Donati; Juan A Oliver; Michio Hirano
Journal:  J Biol Chem       Date:  2001-12-03       Impact factor: 5.157

5.  Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes.

Authors:  Pierre Vaudaux; Patrice Francois; Carmelo Bisognano; William L Kelley; Daniel P Lew; Jacques Schrenzel; Richard A Proctor; Peter J McNamara; G Peters; Christof Von Eiff
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

6.  Thymidine concentrations in human sera: variations in patients with leukaemia and megaloblastic anaemia.

Authors:  L Holden; A V Hoffbrand; M H Tattersall
Journal:  Eur J Cancer       Date:  1980-01       Impact factor: 9.162

7.  Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation.

Authors:  Barbara C Kahl; Gunnar Belling; Rudolf Reichelt; Mathias Herrmann; Richard A Proctor; Georg Peters
Journal:  J Clin Microbiol       Date:  2003-01       Impact factor: 5.948

8.  Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus.

Authors:  R A Proctor; P van Langevelde; M Kristjansson; J N Maslow; R D Arbeit
Journal:  Clin Infect Dis       Date:  1995-01       Impact factor: 9.079

9.  Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis.

Authors:  P H Gilligan; P A Gage; D F Welch; M J Muszynski; K R Wait
Journal:  J Clin Microbiol       Date:  1987-07       Impact factor: 5.948

10.  The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates.

Authors:  Silke Besier; Johannes Zander; Barbara C Kahl; Peter Kraiczy; Volker Brade; Thomas A Wichelhaus
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191
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  16 in total

1.  Thymidine auxotrophic Staphylococcus aureus small-colony variant endocarditis and left ventricular assist device infection.

Authors:  Awele Maduka-Ezeh; Maria Teresa Seville; Shimon Kusne; Holenarasipur R Vikram; Janis E Blair; Kerryl Greenwood-Quaintance; Francisco Arabia; Robin Patel
Journal:  J Clin Microbiol       Date:  2012-01-11       Impact factor: 5.948

2.  Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.

Authors:  José M Entenza; Andreas Haldimann; Marlyse Giddey; Sergio Lociuro; Stephen Hawser; Philippe Moreillon
Journal:  Antimicrob Agents Chemother       Date:  2009-06-29       Impact factor: 5.191

3.  Synergistic antimicrobial activities of folic acid antagonists and nucleoside analogs.

Authors:  Johannes Zander; Silke Besier; Hanns Ackermann; Thomas A Wichelhaus
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

Review 4.  Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections.

Authors:  Barbara C Kahl; Karsten Becker; Bettina Löffler
Journal:  Clin Microbiol Rev       Date:  2016-04       Impact factor: 26.132

5.  Optimized In Vitro Antibiotic Susceptibility Testing Method for Small-Colony Variant Staphylococcus aureus.

Authors:  Mimi R Precit; Daniel J Wolter; Adam Griffith; Julia Emerson; Jane L Burns; Lucas R Hoffman
Journal:  Antimicrob Agents Chemother       Date:  2016-01-04       Impact factor: 5.191

Review 6.  Small colony variants of Staphylococcus aureus--review.

Authors:  O Melter; B Radojevič
Journal:  Folia Microbiol (Praha)       Date:  2011-01-21       Impact factor: 2.099

7.  Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.

Authors:  Hoang Anh Nguyen; Olivier Denis; Anne Vergison; Anne Theunis; Paul M Tulkens; Marc J Struelens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

8.  In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics.

Authors:  Evgeny A Idelevich; André Kriegeskorte; Nina Schleimer; Georg Peters; Christof von Eiff; Karsten Becker
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

9.  Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge.

Authors:  Andre Kriegeskorte; Nicola Ivan Lorè; Alessandra Bragonzi; Camilla Riva; Marco Kelkenberg; Karsten Becker; Richard A Proctor; Georg Peters; Barbara C Kahl
Journal:  Antimicrob Agents Chemother       Date:  2015-09-14       Impact factor: 5.191

10.  Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor.

Authors:  Sandeep Chhabra; Olan Dolezal; Brett M Collins; Janet Newman; Jamie S Simpson; Ian G Macreadie; Ross Fernley; Thomas S Peat; James D Swarbrick
Journal:  PLoS One       Date:  2012-01-19       Impact factor: 3.240
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