Literature DB >> 29378720

In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics.

Evgeny A Idelevich1, André Kriegeskorte1, Nina Schleimer1, Georg Peters1, Christof von Eiff1, Karsten Becker2.   

Abstract

The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-lactam and non-β-lactam antibiotics in vitro as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureus; aminoglycosides; antibiotic resistance; daptomycin; lincosamides; linezolid; resistance; small-colony variants; susceptibility; trimethoprim; β-lactam antibiotics

Mesh：

Substances：

Year:  2018        PMID： 29378720      PMCID： PMC5913952          DOI： 10.1128/AAC.02532-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Rapid method for epidemiological evaluation of gram-positive cocci by field inversion gel electrophoresis.

Authors:  R V Goering; M A Winters
Journal:  J Clin Microbiol       Date:  1992-03       Impact factor: 5.948

2.  Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.

Authors:  Gabriel Mitchell; Mariza Gattuso; Gilles Grondin; Éric Marsault; Kamal Bouarab; François Malouin
Journal:  Antimicrob Agents Chemother       Date:  2011-02-28       Impact factor: 5.191

3.  Transcription of virulence factors in Staphylococcus aureus small-colony variants isolated from cystic fibrosis patients is influenced by SigB.

Authors:  Hélène Moisan; Eric Brouillette; Christian Lebeau Jacob; Philippe Langlois-Bégin; Sophie Michaud; François Malouin
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

4.  Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.

Authors:  Hoang Anh Nguyen; Olivier Denis; Anne Vergison; Anne Theunis; Paul M Tulkens; Marc J Struelens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

5.  Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo.

Authors:  Eric Brouillette; Alejandro Martinez; Bobbi J Boyll; Norris E Allen; François Malouin
Journal:  FEMS Immunol Med Microbiol       Date:  2004-05-01

6.  sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.

Authors:  Malcolm J Horsburgh; Joanne L Aish; Ian J White; Les Shaw; James K Lithgow; Simon J Foster
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

7.  Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.

Authors:  L G Garcia; S Lemaire; B C Kahl; K Becker; R A Proctor; O Denis; P M Tulkens; F Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2012-05-07       Impact factor: 5.191

8.  Staphylococcus aureus-Associated Musculoskeletal Infections.

Authors:  Evgeny A Idelevich; Carolin Kreis; Bettina Löffler; Georg Peters
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

9.  Staphylococcus aureus small colony variants show common metabolic features in central metabolism irrespective of the underlying auxotrophism.

Authors:  André Kriegeskorte; Stephanie Grubmüller; Claudia Huber; Barbara C Kahl; Christof von Eiff; Richard A Proctor; Georg Peters; Wolfgang Eisenreich; Karsten Becker
Journal:  Front Cell Infect Microbiol       Date:  2014-10-21       Impact factor: 5.293

10.  Inactivation of thyA in Staphylococcus aureus attenuates virulence and has a strong impact on metabolism and virulence gene expression.

Authors:  Andre Kriegeskorte; Desiree Block; Mike Drescher; Nadine Windmüller; Alexander Mellmann; Cathrin Baum; Claudia Neumann; Nicola Ivan Lorè; Alessandra Bragonzi; Eva Liebau; Patrick Hertel; Jochen Seggewiss; Karsten Becker; Richard A Proctor; Georg Peters; Barbara C Kahl
Journal:  MBio       Date:  2014-07-29       Impact factor: 7.867
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  2 in total

1.  Activity of Antibiotics against Staphylococcus aureus in an In Vitro Model of Biofilms in the Context of Cystic Fibrosis: Influence of the Culture Medium.

Authors:  Yvan Diaz Iglesias; Tobias Wilms; Rita Vanbever; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

2.  Extracellular DNA released by glycine-auxotrophic Staphylococcus epidermidis small colony variant facilitates catheter-related infections.

Authors:  Junlan Liu; Zhen Shen; Jin Tang; Qian Huang; Ying Jian; Yao Liu; Yanan Wang; Xiaowei Ma; Qian Liu; Lei He; Min Li
Journal:  Commun Biol       Date:  2021-07-22
  2 in total

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