BACKGROUND: The role of Helicobacter pylori (HP) in patients scheduled and undergoing laparoscopic sleeve gastrectomy (LSG) has not been previously evaluated. METHODS: Included were obese patients presenting to our institution for LSG over 24 months. All patients had presurgical HP breath test, and the symptomatic ones received triple therapy with symptom follow-up. Post surgery, all excluded stomachs were evaluated for HP, and those that were positive performed a second 13C-urea breath test (UBT) 3 months later. RESULTS: Forty patients underwent LSG. Male to female sex ratio was 1:3; mean age-42 years; mean weight-122 kg; and mean BMI of 43.4 kg/m2. Presurgical HP was positive in 15 (37.5%) patients (11 symptomatic and four asymptomatic). Only these 11 patients were given HP eradication therapy and all experienced complete subsequent symptom resolution. HP was detected in 17 out of the 40 (42.5%) cases of excluded stomachs. All performed a 13C-UBT 3 months post operation and only three (17.6%) tested positive. CONCLUSIONS: HP infection is frequent in biopsies from patients with previous LSG and the majority of follow-up 13C-UBT were negative. In our small initial sample, we treated only symptomatic patients preoperatively. Routine screening for HP for all LSG patients and/or treatment for all positive ones would subject patients to expensive and unnecessary investigations. We propose that this stomach-reducing, pylorus-preserving surgery might even lead to HP eradication. The clinical implications of HP and this gastrectomy for a non-neoplastic, non-peptic indication deserve further study.
BACKGROUND: The role of Helicobacter pylori (HP) in patients scheduled and undergoing laparoscopic sleeve gastrectomy (LSG) has not been previously evaluated. METHODS: Included were obesepatients presenting to our institution for LSG over 24 months. All patients had presurgical HP breath test, and the symptomatic ones received triple therapy with symptom follow-up. Post surgery, all excluded stomachs were evaluated for HP, and those that were positive performed a second 13C-urea breath test (UBT) 3 months later. RESULTS: Forty patients underwent LSG. Male to female sex ratio was 1:3; mean age-42 years; mean weight-122 kg; and mean BMI of 43.4 kg/m2. Presurgical HP was positive in 15 (37.5%) patients (11 symptomatic and four asymptomatic). Only these 11 patients were given HP eradication therapy and all experienced complete subsequent symptom resolution. HP was detected in 17 out of the 40 (42.5%) cases of excluded stomachs. All performed a 13C-UBT 3 months post operation and only three (17.6%) tested positive. CONCLUSIONS:HP infection is frequent in biopsies from patients with previous LSG and the majority of follow-up 13C-UBT were negative. In our small initial sample, we treated only symptomatic patients preoperatively. Routine screening for HP for all LSG patients and/or treatment for all positive ones would subject patients to expensive and unnecessary investigations. We propose that this stomach-reducing, pylorus-preserving surgery might even lead to HP eradication. The clinical implications of HP and this gastrectomy for a non-neoplastic, non-peptic indication deserve further study.
Authors: Melinda A Maggard; Lisa R Shugarman; Marika Suttorp; Margaret Maglione; Harvey J Sugerman; Harvey J Sugarman; Edward H Livingston; Ninh T Nguyen; Zhaoping Li; Walter A Mojica; Lara Hilton; Shannon Rhodes; Sally C Morton; Paul G Shekelle Journal: Ann Intern Med Date: 2005-04-05 Impact factor: 25.391
Authors: Y T Lee; J J Sung; C L Choi; F K Chan; E K Ng; J Y Ching; W K Leung; S C Chung Journal: Am J Gastroenterol Date: 1998-06 Impact factor: 10.864
Authors: Jonathan P Bradfield; H Rob Taal; Nicholas J Timpson; André Scherag; Cecile Lecoeur; Nicole M Warrington; Elina Hypponen; Claus Holst; Beatriz Valcarcel; Elisabeth Thiering; Rany M Salem; Fredrick R Schumacher; Diana L Cousminer; Patrick M A Sleiman; Jianhua Zhao; Robert I Berkowitz; Karani S Vimaleswaran; Ivonne Jarick; Craig E Pennell; David M Evans; Beate St Pourcain; Diane J Berry; Dennis O Mook-Kanamori; Albert Hofman; Fernando Rivadeneira; André G Uitterlinden; Cornelia M van Duijn; Ralf J P van der Valk; Johan C de Jongste; Dirkje S Postma; Dorret I Boomsma; W James Gauderman; Mohamed T Hassanein; Cecilia M Lindgren; Reedik Mägi; Colin A G Boreham; Charlotte E Neville; Luis A Moreno; Paul Elliott; Anneli Pouta; Anna-Liisa Hartikainen; Mingyao Li; Olli Raitakari; Terho Lehtimäki; Johan G Eriksson; Aarno Palotie; Jean Dallongeville; Shikta Das; Panos Deloukas; George McMahon; Susan M Ring; John P Kemp; Jessica L Buxton; Alexandra I F Blakemore; Mariona Bustamante; Mònica Guxens; Joel N Hirschhorn; Matthew W Gillman; Eskil Kreiner-Møller; Hans Bisgaard; Frank D Gilliland; Joachim Heinrich; Eleanor Wheeler; Inês Barroso; Stephen O'Rahilly; Aline Meirhaeghe; Thorkild I A Sørensen; Chris Power; Lyle J Palmer; Anke Hinney; Elisabeth Widen; I Sadaf Farooqi; Mark I McCarthy; Philippe Froguel; David Meyre; Johannes Hebebrand; Marjo-Riitta Jarvelin; Vincent W V Jaddoe; George Davey Smith; Hakon Hakonarson; Struan F A Grant Journal: Nat Genet Date: 2012-05 Impact factor: 38.330
Authors: Anıl Ergin; Hüseyin Çiyiltepe; Aziz Bora Karip; Mehmet Mahir Fersahoğlu; Nuriye Esen Bulut; Ahmet Çakmak; Berk Topaloğlu; Ali Cihan Bilgili; Adnan Somay; İksan Taşdelen; Ümit Akyüz; Kemal Memişoğlu Journal: Obes Surg Date: 2021-06-01 Impact factor: 4.129