Literature DB >> 18828015

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers.

Fabien Chauveau1, Hervé Boutin, Nadja Van Camp, Frédéric Dollé, Bertrand Tavitian.   

Abstract

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [(11)C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [(11)C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents.

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Year:  2008        PMID： 18828015     DOI： 10.1007/s00259-008-0908-9

Source DB:  PubMed          Journal:  Eur J Nucl Med Mol Imaging        ISSN： 1619-7070            Impact factor:   9.236


  134 in total

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4.  Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage.

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7.  Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.

Authors:  Weiping Yu; Eric Wang; Ronald J Voll; Andrew H Miller; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2008-04-25       Impact factor: 3.641

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Review 10.  Visualising microglial activation in vivo.

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  162 in total

Review 1.  Positron emission tomography in acute coronary syndromes.

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Journal:  J Cardiovasc Transl Res       Date:  2011-12-15       Impact factor: 4.132

2.  Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study.

Authors:  Arthur L Brody; Robert Hubert; Ryutaro Enoki; Lizette Y Garcia; Michael S Mamoun; Kyoji Okita; Edythe D London; Erika L Nurmi; Lauren C Seaman; Mark A Mandelkern
Journal:  Neuropsychopharmacology       Date:  2017-03-06       Impact factor: 7.853

Review 3.  Molecular imaging of microglia/macrophages in the brain.

Authors:  Sriram Venneti; Brian J Lopresti; Clayton A Wiley
Journal:  Glia       Date:  2012-05-21       Impact factor: 7.452

Review 4.  Positron emission tomography molecular imaging in late-life depression.

Authors:  Kentaro Hirao; Gwenn S Smith
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5.  Neuroinflammation in treated HIV-positive individuals: A TSPO PET study.

Authors:  Jaime H Vera; Qi Guo; James H Cole; Adriano Boasso; Louise Greathead; Peter Kelleher; Eugenii A Rabiner; Nicola Kalk; Courtney Bishop; Roger N Gunn; Paul M Matthews; Alan Winston
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6.  New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents.

Authors:  Nunzio Denora; Valentino Laquintana; Adriana Trapani; Hiromi Suzuki; Makoto Sawada; Giuseppe Trapani
Journal:  Pharm Res       Date:  2011-08-05       Impact factor: 4.200

Review 7.  Imaging of atherosclerosis.

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8.  [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain.

Authors:  S Lavisse; K Inoue; C Jan; M A Peyronneau; F Petit; S Goutal; J Dauguet; M Guillermier; F Dollé; L Rbah-Vidal; N Van Camp; R Aron-Badin; P Remy; P Hantraye
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-12-09       Impact factor: 9.236

9.  Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa).

Authors:  Yota Fujimura; Yasuyuki Kimura; Fabrice G Siméon; Leah P Dickstein; Victor W Pike; Robert B Innis; Masahiro Fujita
Journal:  J Nucl Med       Date:  2009-12-15       Impact factor: 10.057

10.  Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis.

Authors:  J L E Bird; D Izquierdo-Garcia; J R Davies; J H F Rudd; K C Probst; N Figg; J C Clark; P L Weissberg; A P Davenport; E A Warburton
Journal:  Atherosclerosis       Date:  2009-12-04       Impact factor: 5.162
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