Literature DB >> 22615180

Molecular imaging of microglia/macrophages in the brain.

Sriram Venneti1, Brian J Lopresti, Clayton A Wiley.   

Abstract

Neuroinflammation perpetuates neuronal damage in many neurological disorders. Activation of resident microglia and infiltration of monocytes/macrophages contributes to neuronal injury and synaptic damage. Noninvasive imaging of these cells in vivo provides a means to monitor progression of disease as well as assess efficacies of potential therapeutics. This review provides an overview of positron emission tomography (PET) and magnetic resonance (MR) imaging of microglia/macrophages in the brain. We describe the rationale behind PET imaging of microglia/macrophages with ligands that bind to translocator protein-18 kDa (TSPO). We discuss the prototype TSPO radioligand [(11)C]PK11195, its limitations, and the development of newer TSPO ligands as PET imaging agents. PET imaging agents for targets other than TSPO are emerging, and we outline the potential of these agents for imaging brain microglia/macrophage activity in vivo. Finally, we briefly summarize advances in MR imaging of microglia/macrophages using iron oxide nanoparticles and ultra-small super paramagnetic particles that are phagocytosed. Despite many technical advances, more sensitive agents are required to be useful indicators of neuroinflammation in brain.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22615180      PMCID： PMC3580157          DOI： 10.1002/glia.22357

Source DB:  PubMed          Journal:  Glia        ISSN： 0894-1491            Impact factor:   7.452


  100 in total

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Journal:  Neurochem Int       Date:  2010-11-12       Impact factor: 3.921

2.  Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion.

Authors:  R Myers; L G Manjil; B M Cullen; G W Price; R S Frackowiak; J E Cremer
Journal:  J Cereb Blood Flow Metab       Date:  1991-03       Impact factor: 6.200

3.  Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity.

Authors:  A C Kuhlmann; T R Guilarte
Journal:  J Neurochem       Date:  2000-04       Impact factor: 5.372

4.  Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation.

Authors:  C A Colton; J E Keri; W T Chen; W L Monsky
Journal:  J Neurosci Res       Date:  1993-06-15       Impact factor: 4.164

Review 5.  Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

Authors:  Rainer Rupprecht; Vassilios Papadopoulos; Gerhard Rammes; Thomas C Baghai; Jinjiang Fan; Nagaraju Akula; Ghislaine Groyer; David Adams; Michael Schumacher
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6.  Magnetic resonance imaging of cells in experimental disease models.

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8.  Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon.

Authors:  M Awad; M Gavish
Journal:  Life Sci       Date:  1991       Impact factor: 5.037

9.  Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.

Authors:  Jun Maeda; Bin Ji; Toshiaki Irie; Takami Tomiyama; Masahiro Maruyama; Takashi Okauchi; Matthias Staufenbiel; Nobuhisa Iwata; Maiko Ono; Takaomi C Saido; Kazutoshi Suzuki; Hiroshi Mori; Makoto Higuchi; Tetsuya Suhara
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Review 10.  Visualising microglial activation in vivo.

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  79 in total

1.  In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy.

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2.  The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

Authors:  E Cavedo; S Lista; Z Khachaturian; P Aisen; P Amouyel; K Herholz; C R Jack; R Sperling; J Cummings; K Blennow; S O'Bryant; G B Frisoni; A Khachaturian; M Kivipelto; W Klunk; K Broich; S Andrieu; M Thiebaut de Schotten; J-F Mangin; A A Lammertsma; K Johnson; S Teipel; A Drzezga; A Bokde; O Colliot; H Bakardjian; H Zetterberg; B Dubois; B Vellas; L S Schneider; H Hampel
Journal:  J Prev Alzheimers Dis       Date:  2014-12

3.  Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.

Authors:  K Collste; P Plavén-Sigray; H Fatouros-Bergman; P Victorsson; M Schain; A Forsberg; N Amini; S Aeinehband; S Erhardt; C Halldin; L Flyckt; L Farde; S Cervenka
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Review 4.  Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations.

Authors:  Ankit Shah; Marina A Dobrovolskaia
Journal:  Nanomedicine       Date:  2018-02-02       Impact factor: 5.307

5.  In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma.

Authors:  Alejandra Bosco; Cesar O Romero; Balamurali K Ambati; Monica L Vetter
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Review 6.  PET and MR imaging of neuroinflammation in hepatic encephalopathy.

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Journal:  Metab Brain Dis       Date:  2014-12-17       Impact factor: 3.584

Review 7.  In vivo imaging of neuroinflammation in schizophrenia.

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Review 8.  Translocator protein (18 kDa): an update on its function in steroidogenesis.

Authors:  V Papadopoulos; J Fan; B Zirkin
Journal:  J Neuroendocrinol       Date:  2018-02       Impact factor: 3.627

9.  Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies.

Authors:  Daniel García-Lorenzo; Sonia Lavisse; Claire Leroy; Catriona Wimberley; Benedetta Bodini; Philippe Remy; Mattia Veronese; Federico Turkheimer; Bruno Stankoff; Michel Bottlaender
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-09       Impact factor: 6.200

10.  Systemic inflammation regulates microglial responses to tissue damage in vivo.

Authors:  Stefka Gyoneva; Dimitrios Davalos; Dipankar Biswas; Sharon A Swanger; Ethel Garnier-Amblard; Francis Loth; Katerina Akassoglou; Stephen F Traynelis
Journal:  Glia       Date:  2014-05-07       Impact factor: 7.452
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