UNLABELLED: As a PET biomarker for inflammation, translocator protein (18 kDa) (TSPO) can be measured with an (18)F-labeled aryloxyanilide, (18)F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline ((18)F-PBR06), in the human brain. The objective of this study was to estimate the radiation absorbed doses of (18)F-PBR06 based on biodistribution data in humans. METHODS: After the injection of (18)F-PBR06, images were acquired from head to thigh in 7 healthy humans. Urine was collected at various time points. Radiation absorbed doses were estimated by the MIRD scheme. RESULTS: Moderate to high levels of radioactivity were observed in organs with high densities of TSPO and in organs of metabolism and excretion. Bone had low levels of radioactivity. The effective dose was 18.5 muSv/MBq. CONCLUSION: The effective dose of (18)F-PBR06, compared with other (18)F radioligands, was moderate. This radioligand had negligible defluorination, as indirectly assessed by bone radioactivity. Doses to the gallbladder wall and spleen may limit the amount of permissible injected radioactivity.
UNLABELLED: As a PET biomarker for inflammation, translocator protein (18 kDa) (TSPO) can be measured with an (18)F-labeled aryloxyanilide, (18)F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline ((18)F-PBR06), in the human brain. The objective of this study was to estimate the radiation absorbed doses of (18)F-PBR06 based on biodistribution data in humans. METHODS: After the injection of (18)F-PBR06, images were acquired from head to thigh in 7 healthy humans. Urine was collected at various time points. Radiation absorbed doses were estimated by the MIRD scheme. RESULTS: Moderate to high levels of radioactivity were observed in organs with high densities of TSPO and in organs of metabolism and excretion. Bone had low levels of radioactivity. The effective dose was 18.5 muSv/MBq. CONCLUSION: The effective dose of (18)F-PBR06, compared with other (18)F radioligands, was moderate. This radioligand had negligible defluorination, as indirectly assessed by bone radioactivity. Doses to the gallbladder wall and spleen may limit the amount of permissible injected radioactivity.
Authors: Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; John L Musachio; Robert Gladding; Victor W Pike; Robert B Innis; Masahiro Fujita Journal: Synapse Date: 2007-08 Impact factor: 2.562
Authors: Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; Yota Fujimura; Victor W Pike; Robert B Innis; Masahiro Fujita Journal: Neuroimage Date: 2007-10-12 Impact factor: 6.556
Authors: Emmanuelle Briard; Sami S Zoghbi; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Jinsoo Hong; Vanessa Cropley; Masahiro Fujita; Robert B Innis; Victor W Pike Journal: J Med Chem Date: 2007-12-08 Impact factor: 7.446
Authors: Emmanuelle Briard; Sami S Zoghbi; Fabrice G Siméon; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Shuiyu Lu; Masahiro Fujita; Robert B Innis; Victor W Pike Journal: J Med Chem Date: 2009-02-12 Impact factor: 7.446
Authors: Christopher J R Fookes; Tien Q Pham; Filomena Mattner; Ivan Greguric; Christian Loc'h; Xiang Liu; Paula Berghofer; Rachael Shepherd; Marie-Claude Gregoire; Andrew Katsifis Journal: J Med Chem Date: 2008-06-17 Impact factor: 7.446
Authors: Frederick M Lartey; G-One Ahn; Bin Shen; Keith-Travis Cord; Tenille Smith; Joshua Y Chua; Sahar Rosenblum; Hongguang Liu; Michelle L James; Sophia Chernikova; Star W Lee; Laura J Pisani; Rabindra Tirouvanziam; John W Chen; Theo D Palmer; Frederick T Chin; Raphael Guzman; Edward E Graves; Billy W Loo Journal: Mol Imaging Biol Date: 2013-07-09 Impact factor: 3.488
Authors: Romina Mizrahi; Pablo M Rusjan; Irina Vitcu; Alvina Ng; Alan A Wilson; Sylvain Houle; Peter M Bloomfield Journal: Mol Imaging Biol Date: 2013-06 Impact factor: 3.488
Authors: Leah P Dickstein; Sami S Zoghbi; Yota Fujimura; Masao Imaizumi; Yi Zhang; Victor W Pike; Robert B Innis; Masahiro Fujita Journal: Eur J Nucl Med Mol Imaging Date: 2010-11-18 Impact factor: 9.236
Authors: Michelle L James; Nadia P Belichenko; Thuy-Vi V Nguyen; Lauren E Andrews; Zhaoqing Ding; Hongguang Liu; Deepika Bodapati; Natasha Arksey; Bin Shen; Zhen Cheng; Tony Wyss-Coray; Sanjiv S Gambhir; Frank M Longo; Frederick T Chin Journal: J Nucl Med Date: 2015-01-22 Impact factor: 10.057
Authors: Kornelis S M van der Geest; Maria Sandovici; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Elisabeth Brouwer; William F Jiemy Journal: Front Med (Lausanne) Date: 2022-06-06
Authors: Dewei Tang; Eliot T McKinley; Matthew R Hight; Md Imam Uddin; Joel M Harp; Allie Fu; Michael L Nickels; Jason R Buck; H Charles Manning Journal: J Med Chem Date: 2013-04-03 Impact factor: 7.446
Authors: Bin Liu; Kevin X Le; Mi-Ae Park; Shuyan Wang; Anthony P Belanger; Shipra Dubey; Jeffrey L Frost; Peter Holton; Vladimir Reiser; Paul A Jones; William Trigg; Marcelo F Di Carli; Cynthia A Lemere Journal: J Neurosci Date: 2015-11-25 Impact factor: 6.167