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Literature DB >> 18808125

Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA.

Abstract

We report a deoxyribozyme (DNA enzyme) that catalyzes the convergent and general synthesis of branched DNA. The 15HA9 deoxyribozyme mediates nucleophilic attack of the 2'-hydroxyl group of a ribonucleotide embedded within one DNA substrate into a 5'-adenylate of the second DNA substrate. This approach can be used to synthesize multiply branched DNA with a wide range of DNA sequences.

Entities: Chemical Species

Mesh：

Substances：
DNA, Catalytic
DNA

Year: 2008 PMID： 18808125 PMCID： PMC2628329 DOI： 10.1021/ol801568q

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

35 in total

1. Ligase-mediated construction of branched DNA strands: a novel DNA joining activity catalyzed by T4 DNA ligase.

Authors: Maritha Mendel-Hartvig; Anil Kumar; Ulf Landegren
Journal: Nucleic Acids Res Date: 2004-01-02 Impact factor: 16.971

2. DNA nanotechnology: Chemical copying of connectivity.

Authors: Lars Henning Eckardt; Kai Naumann; Wolf Matthias Pankau; Michael Rein; Markus Schweitzer; Norbert Windhab; Günter von Kiedrowski
Journal: Nature Date: 2002-11-21 Impact factor: 49.962

3. A deoxyribozyme that forms a three-helix-junction complex with its RNA substrates and has general RNA branch-forming activity.

Authors: Rebecca L Coppins; Scott K Silverman
Journal: J Am Chem Soc Date: 2005-03-09 Impact factor: 15.419

4. A novel method to synthesize versatile multiple-branched DNA (MB-DNA) by reversible photochemical ligation.

Authors: Shinzi Ogasawara; Kenzo Fujimoto
Journal: Chembiochem Date: 2005-10 Impact factor: 3.164

Review 5. DNA catalysis: potential, limitations, open questions.

Authors: Alessio Peracchi
Journal: Chembiochem Date: 2005-08 Impact factor: 3.164

6. Improvement of DNA adenylation using T4 DNA ligase with a template strand and a strategically mismatched acceptor strand.

Authors: Maha P Patel; Dana A Baum; Scott K Silverman
Journal: Bioorg Chem Date: 2007-11-26 Impact factor: 5.275

Review 7. An overview of structural DNA nanotechnology.

Authors: Nadrian C Seeman
Journal: Mol Biotechnol Date: 2007-07-12 Impact factor: 2.695

8. Chemical synthesis and characterization of branched oligodeoxyribonucleotides (bDNA) for use as signal amplifiers in nucleic acid quantification assays.

Authors: T Horn; C A Chang; M S Urdea
Journal: Nucleic Acids Res Date: 1997-12-01 Impact factor: 16.971

Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA.

1. Ligase-mediated construction of branched DNA strands: a novel DNA joining activity catalyzed by T4 DNA ligase.

2. DNA nanotechnology: Chemical copying of connectivity.

3. A deoxyribozyme that forms a three-helix-junction complex with its RNA substrates and has general RNA branch-forming activity.

4. A novel method to synthesize versatile multiple-branched DNA (MB-DNA) by reversible photochemical ligation.

Review 5. DNA catalysis: potential, limitations, open questions.

6. Improvement of DNA adenylation using T4 DNA ligase with a template strand and a strategically mismatched acceptor strand.

Review 7. An overview of structural DNA nanotechnology.

8. Chemical synthesis and characterization of branched oligodeoxyribonucleotides (bDNA) for use as signal amplifiers in nucleic acid quantification assays.

9. A DNA enzyme that mimics the first step of RNA splicing.

10. Characterization of deoxyribozymes that synthesize branched RNA.

1. Use of deoxyribozymes in RNA research.

Review 2. DNA as a versatile chemical component for catalysis, encoding, and stereocontrol.

Review 3. Deoxyribozymes: selection design and serendipity in the development of DNA catalysts.

4. Improved deoxyribozymes for synthesis of covalently branched DNA and RNA.