Literature DB >> 18806952

GPR12 selections of the metabolites from an endophytic Streptomyces sp. associated with Cistanches deserticola.

Zhen-Jian Lin1, Xiao-Ming Lu, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Weiming Zhu.   

Abstract

An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

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Year:  2008        PMID： 18806952     DOI： 10.1007/s12272-001-1276-4

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


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