OBJECTIVE: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. BACKGROUND: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is implicated in linguistic processing and is a highly lateralized brain region. METHOD: Here, we examined STG volumes and asymmetry of STG in WS patients and in age-matched controls. We also correlated volume of STG with a subset of verbal measures. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5-mm contiguous slices, and were used to measure whole gray matter, white matter, and cerebrospinal fluid volumes, and also STG volume. RESULTS: Results revealed significantly reduced intracranial volume in WS patients, compared with controls. Right and left STG were also significantly smaller in WS patients. In addition, compared with normal controls, a lack of normal left >right STG asymmetry was evident in WS. Also of note was the finding that, in contrast to controls, WS patients did not reveal a positive correlation between verbal intelligence quotient and left STG volume, which further suggests a disruption in this region of the brain. CONCLUSIONS: In conclusion, atypical patterns of asymmetry and reduced STG volume in WS were observed, which may, in part, contribute to some of the linguistic impairments found in this cohort of WS patients.
OBJECTIVE: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. BACKGROUND: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is implicated in linguistic processing and is a highly lateralized brain region. METHOD: Here, we examined STG volumes and asymmetry of STG in WSpatients and in age-matched controls. We also correlated volume of STG with a subset of verbal measures. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5-mm contiguous slices, and were used to measure whole gray matter, white matter, and cerebrospinal fluid volumes, and also STG volume. RESULTS: Results revealed significantly reduced intracranial volume in WSpatients, compared with controls. Right and left STG were also significantly smaller in WSpatients. In addition, compared with normal controls, a lack of normal left >right STG asymmetry was evident in WS. Also of note was the finding that, in contrast to controls, WSpatients did not reveal a positive correlation between verbal intelligence quotient and left STG volume, which further suggests a disruption in this region of the brain. CONCLUSIONS: In conclusion, atypical patterns of asymmetry and reduced STG volume in WS were observed, which may, in part, contribute to some of the linguistic impairments found in this cohort of WSpatients.
Authors: P E Barta; G D Pearlson; L B Brill; R Royall; I K McGilchrist; A E Pulver; R E Powers; M F Casanova; A Y Tien; S Frangou; R G Petty Journal: Am J Psychiatry Date: 1997-05 Impact factor: 18.112
Authors: M E Shenton; R Kikinis; F A Jolesz; S D Pollak; M LeMay; C G Wible; H Hokama; J Martin; D Metcalf; M Coleman Journal: N Engl J Med Date: 1992-08-27 Impact factor: 91.245
Authors: J L Tanabe; D Amend; N Schuff; V DiSclafani; F Ezekiel; D Norman; G Fein; M W Weiner Journal: AJNR Am J Neuroradiol Date: 1997-01 Impact factor: 3.825
Authors: Yuning Zhang; Terrie E Inder; Jeffrey J Neil; Donna L Dierker; Dimitrios Alexopoulos; Peter J Anderson; David C Van Essen Journal: Neuroimage Date: 2015-01-20 Impact factor: 6.556