Literature DB >> 18794382

In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus.

Paul E Verweij1, Debbie T A Te Dorsthorst, Willem H P Janssen, Jacques F G M Meis, Johan W Mouton.   

Abstract

The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.

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Year:  2008        PMID： 18794382      PMCID： PMC2592878          DOI： 10.1128/AAC.00491-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions.

Authors:  A Vermes; H J Guchelaar; J Dankert
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

2.  Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates.

Authors:  D T A Te Dorsthorst; J W Mouton; C J P van den Beukel; H A L van der Lee; J F G M Meis; P E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

3.  Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America.

Authors:  Thomas J Walsh; Elias J Anaissie; David W Denning; Raoul Herbrecht; Dimitrios P Kontoyiannis; Kieren A Marr; Vicki A Morrison; Brahm H Segal; William J Steinbach; David A Stevens; Jo-Anne van Burik; John R Wingard; Thomas F Patterson
Journal:  Clin Infect Dis       Date:  2008-02-01       Impact factor: 9.079

4.  Efficacy and pharmacodynamics of flucytosine monotherapy in a nonneutropenic murine model of invasive aspergillosis.

Authors:  D T A te Dorsthorst; P E Verweij; J F G M Meis; J W Mouton
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

5.  Evidence for a common transport system for cytosine, adenine and hypoxanthine in Saccharomyces cerevisiae and Candida albicans.

Authors:  A Polak; M Grenson
Journal:  Eur J Biochem       Date:  1973-01-15

Review 6.  Recommendations for managing Aspergillus osteomyelitis and joint infections based on a review of the literature.

Authors:  Andrew Kirby; Ibrahim Hassan; James Burnie
Journal:  J Infect       Date:  2005-10-18       Impact factor: 6.072

7.  Treatment of fungal infections in hematology and oncology--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

Authors:  Angelika Böhme; Markus Ruhnke; Dieter Buchheidt; Meinolf Karthaus; Hermann Einsele; Stefan Guth; Gudrun Heussel; Claus-Peter Heussel; Christian Junghanss; Winfried K Kern; Thomas Kubin; Georg Maschmeyer; Orhan Sezer; Gerda Silling; Thomas Südhoff; Hubert Szelényi Dagger; Andrew J Ullmann
Journal:  Ann Hematol       Date:  2003-09-09       Impact factor: 3.673

8.  Purine-cytosine permease of Saccharomyces cerevisiae. Effect of external pH on nucleobase uptake and binding.

Authors:  D Brèthes; C Napias; E Torchut; J Chevallier
Journal:  Eur J Biochem       Date:  1992-12-15

9.  Amphotericin B versus amphotericin B plus 5-flucytosine: poor results in the treatment of proven systemic mycoses in neutropenic patients.

Authors:  P E Verweij; J P Donnelly; B J Kullberg; J F Meis; B E De Pauw
Journal:  Infection       Date:  1994 Mar-Apr       Impact factor: 3.553

10.  Flucytosine and cryptococcosis: which in vitro test is the best predictor of outcome?

Authors:  M A Viviani; M C Esposto; M Cogliati; A M Tortorano
Journal:  J Chemother       Date:  2003-04       Impact factor: 1.714
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  11 in total

1.  Genetic Diversity and In Vitro Antifungal Susceptibility of 200 Clinical and Environmental Aspergillus flavus Isolates.

Authors:  Mojtaba Taghizadeh-Armaki; Mohammad Taghi Hedayati; Saham Ansari; Saeed Mahdavi Omran; Sasan Saber; Haleh Rafati; Jan Zoll; Henrich A van der Lee; Willem J G Melchers; Paul E Verweij; Seyedmojtaba Seyedmousavi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

2.  Identification of Paecilomyces variotii in clinical samples and settings.

Authors:  Jos Houbraken; Paul E Verweij; Anthonius J M M Rijs; Andrew M Borman; Robert A Samson
Journal:  J Clin Microbiol       Date:  2010-06-02       Impact factor: 5.948

3.  Asymmetrical dose responses shape the evolutionary trade-off between antifungal resistance and nutrient use.

Authors:  Philippe C Després; Angel F Cisneros; Emilie M M Alexander; Ria Sonigara; Cynthia Gagné-Thivierge; Alexandre K Dubé; Christian R Landry
Journal:  Nat Ecol Evol       Date:  2022-09-01       Impact factor: 19.100

4.  The Lysine Demethylases KdmA and KdmB Differently Regulate Asexual Development, Stress Response, and Virulence in Aspergillus fumigatus.

Authors:  Yong-Ho Choi; Min-Woo Lee; Kwang-Soo Shin
Journal:  J Fungi (Basel)       Date:  2022-05-31

5.  Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus.

Authors:  Fabio Gsaller; Takanori Furukawa; Paul D Carr; Bharat Rash; Christoph Jöchl; Margherita Bertuzzi; Elaine M Bignell; Michael J Bromley
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

6.  Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene.

Authors:  Eleftheria Mavridou; Roger J M Brüggemann; Willem J G Melchers; Johan W Mouton; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2009-11-16       Impact factor: 5.191

7.  Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.

Authors:  Zaid Al-Nakeeb; Ajay Sudan; Adam R Jeans; Lea Gregson; Joanne Goodwin; Peter A Warn; Timothy W Felton; Susan J Howard; William W Hope
Journal:  Antimicrob Agents Chemother       Date:  2012-05-21       Impact factor: 5.191

Review 8.  Rodent Models of Invasive Aspergillosis due to Aspergillus fumigatus: Still a Long Path toward Standardization.

Authors:  Guillaume Desoubeaux; Carolyn Cray
Journal:  Front Microbiol       Date:  2017-05-16       Impact factor: 5.640

Review 9.  Central Nervous System Mold Infections in Children with Hematological Malignancies: Advances in Diagnosis and Treatment.

Authors:  Marie Luckowitsch; Henriette Rudolph; Konrad Bochennek; Luciana Porto; Thomas Lehrnbecher
Journal:  J Fungi (Basel)       Date:  2021-02-26

10.  Azole-resistant Aspergillus and Echinocandin-resistant Candida - What are the treatment options?

Authors:  Alison R Novak; Mary E Bradley; Tyree H Kiser; Scott W Mueller
Journal:  Curr Fungal Infect Rep       Date:  2020-03-26
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