OBJECTIVE: To compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for contrast-enhanced magnetic resonance (MR) angiography of the supraaortic vessels at 3 Tesla. MATERIALS AND METHODS: Twelve healthy volunteers each underwent twocontrast-enhanced magnetic resonance angiography examinations, one with Gd-BOPTA and one with Gd-DTPA each at a dose of 0.1 mmol/kg bodyweight. The 2 examinations were performed in randomized order and were separated by at least 72 hours. Imaging was performed in the coronal plane at 3T (Magnetom TIM Trio Siemens) using a 12-channel neurovascular array coil. The MR sequence parameters were identical for all examinations. Maximum intensity projection reconstructions were evaluated separately and in matched-pairs by a single independent blinded reviewer in terms of qualitative (5-point scales for technical quality and vessel delineation) and quantitative (relative contrast-to-noise ratio) contrast enhancement across 19 arteries/arterial segments comprising the internal carotid arteries; anterior, middle, and posterior cerebral arteries; vertebral arteries; and basilar artery. Findings were compared using the Wilcoxon signed rank test. RESULTS: The mean technical quality across all examinations was significantly (P = 0.031) greater after Gd-BOPTA. The overall median score for vessel delineation was also significantly higher for Gd-BOPTA than for Gd-DTPA (4.3 vs. 3.7; P = 0.005). Matched-pairs assessment revealed significant (P <or= 0.026) preference for Gd-BOPTA both globally and for assessments of the extracranial arteries, Circle of Willis and vessels distal to the Circle of Willis. The relative contrast-to-noise ratio was significantly (P <or= 0.021) greater after Gd-BOPTA, with overall increases of 23.3%, 26.7%, and 28.5% noted for the internal carotid, middle cerebral, and basilar arteries, respectively. CONCLUSION: Significantly improved image quality and contrast enhancement is achieved at 3T with 0.1 mmol/kg Gd-BOPTA compared with 0.1 mmol/kg Gd-DTPA.
RCT Entities:
OBJECTIVE: To compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for contrast-enhanced magnetic resonance (MR) angiography of the supraaortic vessels at 3 Tesla. MATERIALS AND METHODS: Twelve healthy volunteers each underwent two contrast-enhanced magnetic resonance angiography examinations, one with Gd-BOPTA and one with Gd-DTPA each at a dose of 0.1 mmol/kg bodyweight. The 2 examinations were performed in randomized order and were separated by at least 72 hours. Imaging was performed in the coronal plane at 3T (Magnetom TIM Trio Siemens) using a 12-channel neurovascular array coil. The MR sequence parameters were identical for all examinations. Maximum intensity projection reconstructions were evaluated separately and in matched-pairs by a single independent blinded reviewer in terms of qualitative (5-point scales for technical quality and vessel delineation) and quantitative (relative contrast-to-noise ratio) contrast enhancement across 19 arteries/arterial segments comprising the internal carotid arteries; anterior, middle, and posterior cerebral arteries; vertebral arteries; and basilar artery. Findings were compared using the Wilcoxon signed rank test. RESULTS: The mean technical quality across all examinations was significantly (P = 0.031) greater after Gd-BOPTA. The overall median score for vessel delineation was also significantly higher for Gd-BOPTA than for Gd-DTPA (4.3 vs. 3.7; P = 0.005). Matched-pairs assessment revealed significant (P <or= 0.026) preference for Gd-BOPTA both globally and for assessments of the extracranial arteries, Circle of Willis and vessels distal to the Circle of Willis. The relative contrast-to-noise ratio was significantly (P <or= 0.021) greater after Gd-BOPTA, with overall increases of 23.3%, 26.7%, and 28.5% noted for the internal carotid, middle cerebral, and basilar arteries, respectively. CONCLUSION: Significantly improved image quality and contrast enhancement is achieved at 3T with 0.1 mmol/kg Gd-BOPTA compared with 0.1 mmol/kg Gd-DTPA.
Authors: Z Seidl; J Vymazal; M Mechl; M Goyal; M Herman; C Colosimo; M Pasowicz; R Yeung; B Paraniak-Gieszczyk; B Yemen; N Anzalone; A Citterio; G Schneider; S Bastianello; J Ruscalleda Journal: AJNR Am J Neuroradiol Date: 2012-03-01 Impact factor: 3.825
Authors: Yanjun Li; X Li; D Li; J Lu; X Xing; F Yan; Yuan Li; X Wang; R Iezzi; F De Cobelli Journal: AJNR Am J Neuroradiol Date: 2012-10-04 Impact factor: 3.825
Authors: Jens Harald Kramer; Elisabeth Arnoldi; Christopher J François; Andrew L Wentland; Konstantin Nikolaou; Bernd J Wintersperger; Thomas M Grist Journal: Invest Radiol Date: 2013-03 Impact factor: 6.016
Authors: A Doltra; A Skorin; A Hamdan; B Schnackenburg; R Gebker; C Klein; E Nagel; E Fleck; S Kelle Journal: Eur Radiol Date: 2014-05-15 Impact factor: 5.315