Literature DB >> 18783217

A Janus-Wedge DNA triplex with A-W1-T and G-W2-C base triplets.

Han Chen1, Larry W McLaughlin.   

Abstract

A new type of double-stranded DNA targeting format by formation of a Janus-Wedge (J-W) triple helix is described. The "wedge" residue W1 is used for A-T and T-A base pairs while W2 is used for G-C and C-G base pairs. Both wedge residues are attached to a PNA backbone that is designed to insert the probe strand into double-stranded DNA and base pair with both Watson-Crick faces. To study the stability of such an assembly, we have examined the formation of the J-W triplex with various sequences.

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Year:  2008        PMID： 18783217     DOI： 10.1021/ja804607v

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  15 in total

1.  Reprogramming the assembly of unmodified DNA with a small molecule.

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2.  Small Molecule Recognition Triggers Secondary and Tertiary Interactions in DNA Folding and Hammerhead Ribozyme Catalysis.

Authors:  Jie Mao; Chris DeSantis; Dennis Bong
Journal:  J Am Chem Soc       Date:  2017-07-13       Impact factor: 15.419

Review 3.  Synthetic small-molecule RNA ligands: future prospects as therapeutic agents.

Authors:  A Di Giorgio; M Duca
Journal:  Medchemcomm       Date:  2019-04-30       Impact factor: 3.597

4.  Bifacial PNA complexation inhibits enzymatic access to DNA and RNA.

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Journal:  Chembiochem       Date:  2013-11-20       Impact factor: 3.164

5.  Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.

Authors:  Shivaji A Thadke; J Dinithi R Perera; V M Hridya; Kirti Bhatt; Ashif Y Shaikh; Wei-Che Hsieh; Mengshen Chen; Chakicherla Gayathri; Roberto R Gil; Gordon S Rule; Arnab Mukherjee; Charles A Thornton; Danith H Ly
Journal:  Biochemistry       Date:  2018-03-27       Impact factor: 3.162

6.  Duplex Stem Replacement with bPNA+ Triplex Hybrid Stems Enables Reporting on Tertiary Interactions of Internal RNA Domains.

Authors:  Shiqin Miao; Yufeng Liang; Ila Marathe; Jie Mao; Chris DeSantis; Dennis Bong
Journal:  J Am Chem Soc       Date:  2019-05-29       Impact factor: 15.419

7.  Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.

Authors:  Chun-Ho Wong; Stacie L Richardson; Yen-Jun Ho; Alex M H Lucas; Tiziano Tuccinardi; Anne M Baranger; Steven C Zimmerman
Journal:  Chembiochem       Date:  2012-10-24       Impact factor: 3.164

8.  Context-Sensitive Cleavage of Folded DNAs by Loop-Targeting bPNAs.

Authors:  Yufeng Liang; Shiqin Miao; Jie Mao; Chris DeSantis; Dennis Bong
Journal:  Biochemistry       Date:  2020-06-23       Impact factor: 3.162

9.  A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.

Authors:  Jonathan F Arambula; Sreenivasa Rao Ramisetty; Anne M Baranger; Steven C Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-08       Impact factor: 11.205

Review 10.  Unnatural bases for recognition of noncoding nucleic acid interfaces.

Authors:  Shiqin Miao; Yufeng Liang; Sarah Rundell; Debmalya Bhunia; Shekar Devari; Oliver Munyaradzi; Dennis Bong
Journal:  Biopolymers       Date:  2020-09-24       Impact factor: 2.505
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