Literature DB >> 18781329

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.

E K Tan1, Louis C Tan, H Q Lim, R Li, M Tang, Yuen Yih, R Pavanni, K M Prakash, S Fook-Chong, Yi Zhao.   

Abstract

We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.

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Year:  2008        PMID： 18781329     DOI： 10.1007/s00439-008-0544-2

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.

Authors:  Alessio Di Fonzo; Yah-Huei Wu-Chou; Chin-Song Lu; Marina van Doeselaar; Erik J Simons; Christan F Rohé; Hsiu-Chen Chang; Rou-Shayn Chen; Yi-Hsin Weng; Nicola Vanacore; Guido J Breedveld; Ben A Oostra; Vincenzo Bonifati
Journal:  Neurogenetics       Date:  2006-04-22       Impact factor: 2.660

2.  The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.

Authors:  E K Tan; Y Zhao; L Skipper; M G Tan; A Di Fonzo; L Sun; S Fook-Chong; S Tang; E Chua; Y Yuen; L Tan; R Pavanni; M C Wong; P Kolatkar; C S Lu; V Bonifati; J J Liu
Journal:  Hum Genet       Date:  2006-09-30       Impact factor: 4.132

3.  Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

Authors:  Matthew J Farrer; Jeremy T Stone; Chin-Hsien Lin; Justus C Dächsel; Mary M Hulihan; Kristoffer Haugarvoll; Owen A Ross; Ruey-Meei Wu
Journal:  Parkinsonism Relat Disord       Date:  2007-01-10       Impact factor: 4.891

Review 4.  Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.

Authors:  Yi Wei Lu; Eng-King Tan
Journal:  J Neurosci Res       Date:  2008-07       Impact factor: 4.164

5.  Uniting Chinese across Asia: the LRRK2 Gly2385Arg risk variant.

Authors:  E K Tan; A H Schapira
Journal:  Eur J Neurol       Date:  2008-03       Impact factor: 6.089

6.  Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.

Authors:  E K Tan; Lisa Skipper; Eva Chua; Meng-Cheong Wong; Ratnagopal Pavanni; Carine Bonnard; Prasanna Kolatkar; Jian-Jun Liu
Journal:  Mov Disord       Date:  2006-07       Impact factor: 10.338

7.  Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.

Authors:  Owen A Ross; Yih-Ru Wu; Mei-Ching Lee; Manabu Funayama; Meng-Ling Chen; Alexandra I Soto; Ignacio F Mata; Guey-Jen Lee-Chen; Chiung Mei Chen; Michelle Tang; Yi Zhao; Nobutaka Hattori; Matthew J Farrer; Eng-King Tan; Ruey-Meei Wu
Journal:  Ann Neurol       Date:  2008-07       Impact factor: 10.422
  7 in total
  15 in total

1.  Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease.

Authors:  Byoung Dae Lee; Xiaojie Li; Ted M Dawson; Valina L Dawson
Journal:  Methods Mol Biol       Date:  2012

2.  Association between G2385R and R1628P polymorphism of LRRK2 gene and sporadic Parkinson's disease in a Han-Chinese population in south-eastern China.

Authors:  Jiangping Cai; Yi Lin; Wanjin Chen; Qifang Lin; Bin Cai; Ning Wang; Weihong Zheng
Journal:  Neurol Sci       Date:  2013-04-30       Impact factor: 3.307

Review 3.  Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.

Authors:  Iakov N Rudenko; Mark R Cookson
Journal:  Neurotherapeutics       Date:  2014-10       Impact factor: 7.620

4.  LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson's disease patients.

Authors:  Soraya Bardien; Angelica Marsberg; Rowena Keyser; Debbie Lombard; Suzanne Lesage; Alexis Brice; Jonathan Carr
Journal:  J Neural Transm (Vienna)       Date:  2010-06-11       Impact factor: 3.575

Review 5.  Genetic susceptibility in Parkinson's disease.

Authors:  Jose Miguel Bras; Andrew Singleton
Journal:  Biochim Biophys Acta       Date:  2008-11-20

Review 6.  Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.

Authors:  Payal N Gandhi; Shu G Chen; Amy L Wilson-Delfosse
Journal:  J Neurosci Res       Date:  2009-05-01       Impact factor: 4.164

7.  Understanding the role of genetic variability in LRRK2 in Indian population.

Authors:  Asha Kishore; Ashwin Ashok Kumar Sreelatha; Marc Sturm; Felix von-Zweydorf; Lasse Pihlstrøm; Francesco Raimondi; Rob Russell; Peter Lichtner; Moinak Banerjee; Syam Krishnan; Roopa Rajan; Divya Kalikavil Puthenveedu; Sun Ju Chung; Peter Bauer; Olaf Riess; Christian Johannes Gloeckner; Rejko Kruger; Thomas Gasser; Manu Sharma
Journal:  Mov Disord       Date:  2018-11-28       Impact factor: 10.338

Review 8.  Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.

Authors:  Karen Nuytemans; Jessie Theuns; Marc Cruts; Christine Van Broeckhoven
Journal:  Hum Mutat       Date:  2010-07       Impact factor: 4.878

Review 9.  Leucine-rich repeat kinase 2-linked Parkinson's disease: clinical and molecular findings.

Authors:  Udhaya Kumari; Eng-King Tan
Journal:  J Mov Disord       Date:  2010-10-30

10.  LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.

Authors:  April Reynolds; Elizabeth A Doggett; Steve M Riddle; Connie S Lebakken; R Jeremy Nichols
Journal:  Front Mol Neurosci       Date:  2014-06-24       Impact factor: 5.639
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