Literature DB >> 21960214

Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease.

Byoung Dae Lee1, Xiaojie Li, Ted M Dawson, Valina L Dawson.   

Abstract

Mutations in the LRRK2 (Leucine-Rich Repeat Kinase 2) gene are the most common cause of autosomal dominant Parkinson's disease. LRRK2 has multiple functional domains including a kinase domain. The kinase activity of LRRK2 is implicated in the pathogenesis of Parkinson's disease. Developing an assay to understand the mechanisms of LRRK2 kinase activity is important for the development of pharmacologic and therapeutic applications. Here, we describe how to measure in vitro LRRK2 kinase activity and its inhibition.

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Year:  2012        PMID： 21960214      PMCID： PMC4433534          DOI： 10.1007/978-1-61779-337-0_3

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  19 in total

1.  Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

Authors:  Andrew B West; Darren J Moore; Catherine Choi; Shaida A Andrabi; Xiaojie Li; Dustin Dikeman; Saskia Biskup; Zhenshui Zhang; Kah-Leong Lim; Valina L Dawson; Ted M Dawson
Journal:  Hum Mol Genet       Date:  2007-01-02       Impact factor: 6.150

2.  Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.

Authors:  Gianluca Floris; Antonino Cannas; Paolo Solla; Maria Rita Murru; Stefania Tranquilli; Daniela Corongiu; Marcella Rolesu; Stefania Cuccu; Claudia Sardu; Francesco Marrosu; Maria Giovanna Marrosu
Journal:  Parkinsonism Relat Disord       Date:  2008-09-20       Impact factor: 4.891

3.  Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

Authors:  Andrew B West; Darren J Moore; Saskia Biskup; Artem Bugayenko; Wanli W Smith; Christopher A Ross; Valina L Dawson; Ted M Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-03       Impact factor: 11.205

Review 4.  Genetics of Parkinson's disease.

Authors:  Huw R Morris
Journal:  Ann Med       Date:  2005       Impact factor: 4.709

5.  LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.

Authors:  E K Tan; Louis C Tan; H Q Lim; R Li; M Tang; Yuen Yih; R Pavanni; K M Prakash; S Fook-Chong; Yi Zhao
Journal:  Hum Genet       Date:  2008-09-10       Impact factor: 4.132

6.  LRRK2 P755L variant in sporadic Parkinson's disease.

Authors:  Hiroyuki Tomiyama; Ikuko Mizuta; Yuanzhe Li; Manabu Funayama; Hiroyo Yoshino; Lin Li; Miho Murata; Mitsutoshi Yamamoto; Shin-Ichiro Kubo; Yoshikuni Mizuno; Tatsushi Toda; Nobutaka Hattori
Journal:  J Hum Genet       Date:  2008-10-16       Impact factor: 3.172

7.  Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.

Authors:  K Haugarvoll; R Rademakers; J M Kachergus; K Nuytemans; O A Ross; J M Gibson; E-K Tan; C Gaig; E Tolosa; S Goldwurm; M Guidi; G Riboldazzi; L Brown; U Walter; R Benecke; D Berg; T Gasser; J Theuns; P Pals; P Cras; P Paul De Deyn; S Engelborghs; B Pickut; R J Uitti; T Foroud; W C Nichols; J Hagenah; C Klein; A Samii; C P Zabetian; V Bonifati; C Van Broeckhoven; M J Farrer; Z K Wszolek
Journal:  Neurology       Date:  2008-03-12       Impact factor: 9.910

8.  LRRK2 gene G2019S mutation and SNPs [haplotypes] in subtypes of Parkinson's disease.

Authors:  Biswanath Patra; Azemat J Parsian; Brad A Racette; Jing Hua Zhao; Joel S Perlmutter; Abbas Parsian
Journal:  Parkinsonism Relat Disord       Date:  2008-08-26       Impact factor: 4.891

9.  Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

Authors:  Jason P Covy; Benoit I Giasson
Journal:  Biochem Biophys Res Commun       Date:  2008-11-21       Impact factor: 3.575

10.  Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Authors:  Elisa Greggio; Shushant Jain; Ann Kingsbury; Rina Bandopadhyay; Patrick Lewis; Alice Kaganovich; Marcel P van der Brug; Alexandra Beilina; Jeff Blackinton; Kelly Jean Thomas; Rili Ahmad; David W Miller; Sashi Kesavapany; Andrew Singleton; Andrew Lees; Robert J Harvey; Kirsten Harvey; Mark R Cookson
Journal:  Neurobiol Dis       Date:  2006-06-05       Impact factor: 5.996
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  1 in total

Review 1.  New Frontiers in Parkinson's Disease: From Genetics to the Clinic.

Authors:  Lamya S Shihabuddin; Patrik Brundin; J Timothy Greenamyre; Diane Stephenson; S Pablo Sardi
Journal:  J Neurosci       Date:  2018-10-31       Impact factor: 6.167
  1 in total

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