OBJECTIVE: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. DESIGN: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. RESULTS: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. CONCLUSION: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.
OBJECTIVE: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. DESIGN: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. RESULTS: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. CONCLUSION: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.
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Authors: A Luke; X Guo; A A Adeyemo; R Wilks; T Forrester; W Lowe ; A G Comuzzie; L J Martin; X Zhu; C N Rotimi; R S Cooper Journal: Int J Obes Relat Metab Disord Date: 2001-07
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Authors: Lise Dubois; Kirsten Ohm Kyvik; Manon Girard; Fabiola Tatone-Tokuda; Daniel Pérusse; Jacob Hjelmborg; Axel Skytthe; Finn Rasmussen; Margaret J Wright; Paul Lichtenstein; Nicholas G Martin Journal: PLoS One Date: 2012-02-08 Impact factor: 3.240
Authors: Aline Jelenkovic; Yoshie Yokoyama; Reijo Sund; Chika Honda; Leonie H Bogl; Sari Aaltonen; Fuling Ji; Feng Ning; Zengchang Pang; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; S Alexandra Burt; Kelly L Klump; Sarah E Medland; Grant W Montgomery; Christian Kandler; Tom A McAdams; Thalia C Eley; Alice M Gregory; Kimberly J Saudino; Lise Dubois; Michel Boivin; Adam D Tarnoki; David L Tarnoki; Claire M A Haworth; Robert Plomin; Sevgi Y Öncel; Fazil Aliev; Maria A Stazi; Corrado Fagnani; Cristina D'Ippolito; Jeffrey M Craig; Richard Saffery; Sisira H Siribaddana; Matthew Hotopf; Athula Sumathipala; Fruhling Rijsdijk; Timothy Spector; Massimo Mangino; Genevieve Lachance; Margaret Gatz; David A Butler; Gombojav Bayasgalan; Danshiitsoodol Narandalai; Duarte L Freitas; José Antonio Maia; K Paige Harden; Elliot M Tucker-Drob; Bia Kim; Youngsook Chong; Changhee Hong; Hyun Jung Shin; Kaare Christensen; Axel Skytthe; Kirsten O Kyvik; Catherine A Derom; Robert F Vlietinck; Ruth J F Loos; Wendy Cozen; Amie E Hwang; Thomas M Mack; Mingguang He; Xiaohu Ding; Billy Chang; Judy L Silberg; Lindon J Eaves; Hermine H Maes; Tessa L Cutler; John L Hopper; Kelly Aujard; Patrik K E Magnusson; Nancy L Pedersen; Anna K Dahl Aslan; Yun-Mi Song; Sarah Yang; Kayoung Lee; Laura A Baker; Catherine Tuvblad; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Kauko Heikkilä; Qihua Tan; Dongfeng Zhang; Gary E Swan; Ruth Krasnow; Kerry L Jang; Ariel Knafo-Noam; David Mankuta; Lior Abramson; Paul Lichtenstein; Robert F Krueger; Matt McGue; Shandell Pahlen; Per Tynelius; Glen E Duncan; Dedra Buchwald; Robin P Corley; Brooke M Huibregtse; Tracy L Nelson; Keith E Whitfield; Carol E Franz; William S Kremen; Michael J Lyons; Syuichi Ooki; Ingunn Brandt; Thomas Sevenius Nilsen; Fujio Inui; Mikio Watanabe; Meike Bartels; Toos C E M van Beijsterveldt; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Esther Rebato; Nicholas G Martin; Yoshinori Iwatani; Kazuo Hayakawa; Joohon Sung; Jennifer R Harris; Gonneke Willemsen; Andreas Busjahn; Jack H Goldberg; Finn Rasmussen; Yoon-Mi Hur; Dorret I Boomsma; Thorkild I A Sørensen; Jaakko Kaprio; Karri Silventoinen Journal: Twin Res Hum Genet Date: 2015-09-04 Impact factor: 1.587