BACKGROUND: Epithelial ovarian cancer is associated with reproductive factors, but we lack knowledge if hormonal factors during pregnancy influence the mother's risk. Because pregnancy hormones are primarily produced by the placenta, placental weight may be an indirect marker of hormone exposure during pregnancy. METHODS: In a nationwide Swedish cohort study, we included women with singleton births from 1982 to 1989. Women were followed for occurrence of invasive epithelial ovarian cancer, death, or emigration through 2004. Hazard ratios (HR) with 95% confidence intervals (95% CI) from Cox models were used to estimate associations between pregnancy exposures and epithelial ovarian cancer. RESULTS: Among 395,171 women with information on placental weight in their first recorded birth, 316 women developed invasive epithelial ovarian cancer. Mean age at diagnosis was 44 years. Compared with women with a placental weight of 500 to 699 g, women with a high (>or=700 g) placental weight had an increased risk of developing epithelial ovarian cancer (HR, 1.47; 95% CI, 1.14-1.90). Compared with women with term pregnancies (40-41 weeks), women with post-term (>or=42 weeks) pregnancies had an increased risk of developing epithelial ovarian cancer (HR, 1.48; 95% CI, 1.00-2.19). These associations were slightly stronger when we included information about women's overall first birth, and slightly weaker when we included information about last recorded birth or ever last birth from 1982 to 1989. CONCLUSIONS: Because pregnancy hormone levels increase with placental weight, our study supports the hypothesis that hormone exposures during pregnancy influence the risk of invasive epithelial ovarian cancer among young women.
BACKGROUND:Epithelial ovarian cancer is associated with reproductive factors, but we lack knowledge if hormonal factors during pregnancy influence the mother's risk. Because pregnancy hormones are primarily produced by the placenta, placental weight may be an indirect marker of hormone exposure during pregnancy. METHODS: In a nationwide Swedish cohort study, we included women with singleton births from 1982 to 1989. Women were followed for occurrence of invasive epithelial ovarian cancer, death, or emigration through 2004. Hazard ratios (HR) with 95% confidence intervals (95% CI) from Cox models were used to estimate associations between pregnancy exposures and epithelial ovarian cancer. RESULTS: Among 395,171 women with information on placental weight in their first recorded birth, 316 women developed invasive epithelial ovarian cancer. Mean age at diagnosis was 44 years. Compared with women with a placental weight of 500 to 699 g, women with a high (>or=700 g) placental weight had an increased risk of developing epithelial ovarian cancer (HR, 1.47; 95% CI, 1.14-1.90). Compared with women with term pregnancies (40-41 weeks), women with post-term (>or=42 weeks) pregnancies had an increased risk of developing epithelial ovarian cancer (HR, 1.48; 95% CI, 1.00-2.19). These associations were slightly stronger when we included information about women's overall first birth, and slightly weaker when we included information about last recorded birth or ever last birth from 1982 to 1989. CONCLUSIONS: Because pregnancy hormone levels increase with placental weight, our study supports the hypothesis that hormone exposures during pregnancy influence the risk of invasive epithelial ovarian cancer among young women.
Authors: John M Monaghan; Ian M Godber; Nigel Lawson; Malveen Kaur; Gwen Wark; Derrick Teale; David J Hosking Journal: Ann Clin Biochem Date: 2004-05 Impact factor: 2.057
Authors: Annekatrin Lukanova; Eva Lundin; Arslan Akhmedkhanov; Andrea Micheli; Sabina Rinaldi; Anne Zeleniuch-Jacquotte; Per Lenner; Paola Muti; Carine Biessy; Vittorio Krogh; Franco Berrino; Göran Hallmans; Elio Riboli; Rudolf Kaaks; Paolo Toniolo Journal: Int J Cancer Date: 2003-05-01 Impact factor: 7.396
Authors: Annekatrin Lukanova; Eva Lundin; Paolo Toniolo; Andrea Micheli; Arslan Akhmedkhanov; Sabina Rinaldi; Paola Muti; Per Lenner; Carine Biessy; Vittorio Krogh; Anne Zeleniuch-Jacquotte; Franco Berrino; Göran Hallmans; Elio Riboli; Rudolf Kaaks Journal: Int J Cancer Date: 2002-10-20 Impact factor: 7.396
Authors: Lorelei A Mucci; Paul W Dickman; Mats Lambe; Hans-Olov Adami; Dimitrios Trichopoulos; Tomas Riman; Chung-Cheng Hsieh; Sven Cnattingius Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-09 Impact factor: 4.254
Authors: Jennifer David Peck; Barbara S Hulka; David A Savitz; Donna Baird; Charles Poole; Barbara E Richardson Journal: Am J Epidemiol Date: 2003-02-01 Impact factor: 4.897
Authors: Tomas Riman; Paul W Dickman; Staffan Nilsson; Nestor Correia; Hans Nordlinder; Cecilia M Magnusson; Ingemar R Persson Journal: Am J Epidemiol Date: 2002-08-15 Impact factor: 4.897
Authors: Camilla Sköld; Tone Bjørge; Anders Ekbom; Anders Engeland; Mika Gissler; Tom Grotmol; Laura Madanat-Harjuoja; Anne Gulbech Ording; Olof Stephansson; Britton Trabert; Steinar Tretli; Rebecca Troisi; Henrik Toft Sørensen; Ingrid Glimelius Journal: Int J Cancer Date: 2018-07-10 Impact factor: 7.396
Authors: Britton Trabert; Matthew P Longnecker; Barry I Graubard; Mark A Klebanoff; Frank Z Stanczyk; Katherine A McGlynn Journal: Cancer Causes Control Date: 2011-02-19 Impact factor: 2.506
Authors: R Troisi; T Bjørge; M Gissler; T Grotmol; C M Kitahara; S M Myrtveit Saether; A G Ording; C Sköld; H T Sørensen; B Trabert; I Glimelius Journal: J Intern Med Date: 2018-03-25 Impact factor: 8.989