Literature DB >> 18765691

KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate.

Jun-ichiro Sekiguchi1, Koji Morita, Tomoe Kitao, Noboru Watanabe, Mitsuhiro Okazaki, Tohru Miyoshi-Akiyama, Masato Kanamori, Teruo Kirikae.   

Abstract

A novel gene, bla(KHM-1), encoding a metallo-beta-lactamase, KHM-1, was cloned from a clinical isolate of Citrobacter freundii resistant to most beta-lactam antibiotics. Escherichia coli expressing bla(KHM-1) was resistant to all broad-spectrum beta-lactams except for monobactams and showed reduced susceptibility to carbapenems. Recombinant KHM-1 exhibited EDTA-inhibitable hydrolytic activity against most beta-lactams, with an overall preference for cephalosporins.

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Year:  2008        PMID： 18765691      PMCID： PMC2573105          DOI： 10.1128/AAC.01337-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallo-beta-lactamase.

Authors:  Mariana Castanheira; Mark A Toleman; Ronald N Jones; Franz J Schmidt; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

Review 2.  The new beta-lactamases.

Authors:  George A Jacoby; Luisa Silvia Munoz-Price
Journal:  N Engl J Med       Date:  2005-01-27       Impact factor: 91.245

Review 3.  Carbapenem-hydrolyzing beta-lactamases.

Authors:  B A Rasmussen; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

4.  The aminoglycoside-resistance operon of the plasmid pSa: nucleotide sequence of the streptomycin-spectinomycin resistance gene.

Authors:  R C Tait; H Rempel; R L Rodriguez; C I Kado
Journal:  Gene       Date:  1985       Impact factor: 3.688

5.  Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.

Authors:  L Lauretti; M L Riccio; A Mazzariol; G Cornaglia; G Amicosante; R Fontana; G M Rossolini
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

6.  Genetic applications of an inverse polymerase chain reaction.

Authors:  H Ochman; A S Gerber; D L Hartl
Journal:  Genetics       Date:  1988-11       Impact factor: 4.562

Review 7.  Metallo-beta-lactamases: the quiet before the storm?

Authors:  Timothy R Walsh; Mark A Toleman; Laurent Poirel; Patrice Nordmann
Journal:  Clin Microbiol Rev       Date:  2005-04       Impact factor: 26.132

Review 8.  Transposon Tn21, flagship of the floating genome.

Authors:  C A Liebert; R M Hall; A O Summers
Journal:  Microbiol Mol Biol Rev       Date:  1999-09       Impact factor: 11.056

9.  The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics.

Authors:  Matthew W Gilmour; Nicholas R Thomson; Mandy Sanders; Julian Parkhill; Diane E Taylor
Journal:  Plasmid       Date:  2004-11       Impact factor: 3.466

10.  PCR mapping of integrons reveals several novel combinations of resistance genes.

Authors:  C Lévesque; L Piché; C Larose; P H Roy
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191
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  30 in total

1.  Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.

Authors:  Allaaeddin El Salabi; Pardha Saradhi Borra; Mark A Toleman; Ørjan Samuelsen; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

2.  Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

Authors:  Luisa Borgianni; Silvia Prandi; Laurie Salden; Gisela Santella; Nancy D Hanson; Gian Maria Rossolini; Jean-Denis Docquier
Journal:  Antimicrob Agents Chemother       Date:  2010-11-01       Impact factor: 5.191

3.  Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria.

Authors:  Frédéric Robin; Nadjet Aggoune-Khinache; Julien Delmas; Malek Naim; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2009-11-09       Impact factor: 5.191

4.  NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal.

Authors:  Tatsuya Tada; Tohru Miyoshi-Akiyama; Rajan K Dahal; Manoj K Sah; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

5.  NDM-12, a novel New Delhi metallo-β-lactamase variant from a carbapenem-resistant Escherichia coli clinical isolate in Nepal.

Authors:  Tatsuya Tada; Basudha Shrestha; Tohru Miyoshi-Akiyama; Kayo Shimada; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
Journal:  Antimicrob Agents Chemother       Date:  2014-08-04       Impact factor: 5.191

6.  IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.

Authors:  Tatsuya Tada; Tohru Miyoshi-Akiyama; Kayo Shimada; Masahiro Shimojima; Teruo Kirikae
Journal:  Antimicrob Agents Chemother       Date:  2013-07-08       Impact factor: 5.191

7.  SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

Authors:  Jun-ichi Wachino; Hiroyuki Yoshida; Kunikazu Yamane; Satowa Suzuki; Mari Matsui; Takuya Yamagishi; Atsuko Tsutsui; Toshifumi Konda; Keigo Shibayama; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2011-08-29       Impact factor: 5.191

8.  Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.

Authors:  Dongeun Yong; Mark A Toleman; Christian G Giske; Hyun S Cho; Kristina Sundman; Kyungwon Lee; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

9.  IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.

Authors:  Tatsuya Tada; Pham Hong Nhung; Tohru Miyoshi-Akiyama; Kayo Shimada; Doan Mai Phuong; Nguyen Quoc Anh; Norio Ohmagari; Teruo Kirikae
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

10.  Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion.

Authors:  Orjan Samuelsen; Mark A Toleman; Arnfinn Sundsfjord; Johan Rydberg; Truls M Leegaard; Mats Walder; Astrid Lia; Trond E Ranheim; Yashas Rajendra; Nils O Hermansen; Timothy R Walsh; Christian G Giske
Journal:  Antimicrob Agents Chemother       Date:  2009-11-02       Impact factor: 5.191
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