| Literature DB >> 1876184 |
I Ha1, W S Lane, D Reinberg.
Abstract
Transcription factor IIB (TFIIB) has a central role in transcription of class II genes. The purification of the human TFIIB protein and isolation of a complementary DNA encoding TFIIB activity is reported here. The sequence of TFIIB, which seems to be encoded by a single gene, contains a repeated motif, in addition to a motif with similarity to the prokaryotic sigma-factors. The recombinant protein expressed in bacteria substituted for all the functions attributed to the human TFIIB protein.Entities:
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Year: 1991 PMID: 1876184 DOI: 10.1038/352689a0
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962