SUMMARY: In this systematic review, we summarize risk factors for low bone mineral density and bone loss in healthy men age 50 years or older. Consistent risk factors were: age, smoking, low weight, physical/functional limitations, and previous fracture. Data specific to men has clinical and policy implications. INTRODUCTION: Osteoporosis is a significant health care problem in men as well as women, yet the majority of evidence on diagnosis and management of osteoporosis is focused on postmenopausal women. The objective of this systematic review is to examine risk factors for low bone mineral density (BMD) and bone loss in healthy men age 50 years or older. MATERIALS AND METHODS: A systematic search for observational studies was conducted in MEDLINE, Cochrane Database of Systematic Reviews, DARE, CENTRAL, CINAHL and Embase, Health STAR. The three main search concepts were bone density, densitometry, and risk factors. Trained reviewers assessed articles using a priori criteria. RESULTS: Of 642 screened abstracts, 299 articles required a full review, and 25 remained in the final assessment. Consistent risk factors for low BMD/bone loss were: advancing age, smoking, and low weight/weight loss. Although less evidence was available, physical/functional limitations and prevalent fracture (after age 50) were also associated with low BMD/bone loss. The evidence was inconsistent or weak for physical activity, alcohol consumption, calcium intake, muscle strength, family history of fracture/osteoporosis, and height/height loss. CONCLUSION: In this systematic review, we identified several risk factors for low BMD/bone loss in men that are measurable in primary practice.
SUMMARY: In this systematic review, we summarize risk factors for low bone mineral density and bone loss in healthy men age 50 years or older. Consistent risk factors were: age, smoking, low weight, physical/functional limitations, and previous fracture. Data specific to men has clinical and policy implications. INTRODUCTION:Osteoporosis is a significant health care problem in men as well as women, yet the majority of evidence on diagnosis and management of osteoporosis is focused on postmenopausal women. The objective of this systematic review is to examine risk factors for low bone mineral density (BMD) and bone loss in healthy men age 50 years or older. MATERIALS AND METHODS: A systematic search for observational studies was conducted in MEDLINE, Cochrane Database of Systematic Reviews, DARE, CENTRAL, CINAHL and Embase, Health STAR. The three main search concepts were bone density, densitometry, and risk factors. Trained reviewers assessed articles using a priori criteria. RESULTS: Of 642 screened abstracts, 299 articles required a full review, and 25 remained in the final assessment. Consistent risk factors for low BMD/bone loss were: advancing age, smoking, and low weight/weight loss. Although less evidence was available, physical/functional limitations and prevalent fracture (after age 50) were also associated with low BMD/bone loss. The evidence was inconsistent or weak for physical activity, alcohol consumption, calcium intake, muscle strength, family history of fracture/osteoporosis, and height/height loss. CONCLUSION: In this systematic review, we identified several risk factors for low BMD/bone loss in men that are measurable in primary practice.
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Authors: M Lunt; P Masaryk; C Scheidt-Nave; J Nijs; G Poor; H Pols; J A Falch; G Hammermeister; D M Reid; L Benevolenskaya; K Weber; J Cannata; T W O'Neill; D Felsenberg; A J Silman; J Reeve Journal: Osteoporos Int Date: 2001 Impact factor: 4.507
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Authors: Wei Zhou; Lisa Langsetmo; Claudie Berger; Jonathan D Adachi; Alexandra Papaioannou; George Ioannidis; Colin Webber; Stephanie A Atkinson; Wojciech P Olszynski; Jacques P Brown; David A Hanley; Robert Josse; Nancy Kreiger; Jerilynn Prior; Stephanie Kaiser; Susan Kirkland; David Goltzman; Kenneth Shawn Davison Journal: J Clin Densitom Date: 2010-05-31 Impact factor: 2.617
Authors: S Scholtissen; F Guillemin; O Bruyère; J Collette; B Dousset; C Kemmer; S Culot; D Crémer; H Dejardin; G Hubermont; D Lefebvre; V Pascal-Vigneron; G Weryha; J Y Reginster Journal: Osteoporos Int Date: 2008-11-15 Impact factor: 4.507
Authors: Tue Secher Jensen; Per Kjaer; Lars Korsholm; Tom Bendix; Joan S Sorensen; Claus Manniche; Charlotte Leboeuf-Yde Journal: Eur Spine J Date: 2009-11-18 Impact factor: 3.134
Authors: Erik D Swenson; Karen E Hansen; Andrea N Jones; Zhanhai Li; Brooke Baltz-Ward; Arthur A Schuna; Mary E Elliott Journal: Calcif Tissue Int Date: 2013-03-15 Impact factor: 4.333