Literature DB >> 18755832

Mechanistic insights from reversible splicing catalysis.

Duncan J Smith1, Maria M Konarska.   

Abstract

Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

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Year:  2008        PMID： 18755832      PMCID： PMC2553733          DOI： 10.1261/rna.1289808

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  15 in total

1.  Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.

Authors:  Rhonda J Perriman; Manuel Ares
Journal:  Genes Dev       Date:  2007-04-01       Impact factor: 11.361

2.  Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.

Authors:  Li Liu; Charles C Query; Maria M Konarska
Journal:  Nat Struct Mol Biol       Date:  2007-05-07       Impact factor: 15.369

Review 3.  "Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

Authors:  Duncan J Smith; Charles C Query; Maria M Konarska
Journal:  Mol Cell       Date:  2008-06-20       Impact factor: 17.970

4.  Both catalytic steps of nuclear pre-mRNA splicing are reversible.

Authors:  Chi-Kang Tseng; Soo-Chen Cheng
Journal:  Science       Date:  2008-06-27       Impact factor: 47.728

5.  Exon ligation is proofread by the DExD/H-box ATPase Prp22p.

Authors:  Rabiah M Mayas; Hiroshi Maita; Jonathan P Staley
Journal:  Nat Struct Mol Biol       Date:  2006-05-07       Impact factor: 15.369

6.  Group II intron self-splicing. Alternative reaction conditions yield novel products.

Authors:  K A Jarrell; C L Peebles; R C Dietrich; S L Romiti; P S Perlman
Journal:  J Biol Chem       Date:  1988-03-05       Impact factor: 5.157

7.  U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.

Authors:  Angela K Hilliker; Melissa A Mefford; Jonathan P Staley
Journal:  Genes Dev       Date:  2007-04-01       Impact factor: 11.361

8.  Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site.

Authors:  A Brys; B Schwer
Journal:  RNA       Date:  1996-07       Impact factor: 4.942

9.  Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly.

Authors:  Yong-Zhen Xu; Charles C Query
Journal:  Mol Cell       Date:  2007-12-14       Impact factor: 17.970

10.  New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing.

Authors:  T Inoue; F X Sullivan; T R Cech
Journal:  J Mol Biol       Date:  1986-05-05       Impact factor: 5.469
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  5 in total

1.  Conformational dynamics of single pre-mRNA molecules during in vitro splicing.

Authors:  John Abelson; Mario Blanco; Mark A Ditzler; Franklin Fuller; Pavithra Aravamudhan; Mona Wood; Tommaso Villa; Daniel E Ryan; Jeffrey A Pleiss; Corina Maeder; Christine Guthrie; Nils G Walter
Journal:  Nat Struct Mol Biol       Date:  2010-03-21       Impact factor: 15.369

2.  U5 snRNA Interactions With Exons Ensure Splicing Precision.

Authors:  Olga V Artemyeva-Isman; Andrew C G Porter
Journal:  Front Genet       Date:  2021-07-02       Impact factor: 4.599

3.  Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Authors:  Anzhalika Sidarovich; Cindy L Will; Maria M Anokhina; Javier Ceballos; Sonja Sievers; Dmitry E Agafonov; Timur Samatov; Penghui Bao; Berthold Kastner; Henning Urlaub; Herbert Waldmann; Reinhard Lührmann
Journal:  Elife       Date:  2017-03-16       Impact factor: 8.140

Review 4.  The spliceosome: a flexible, reversible macromolecular machine.

Authors:  Aaron A Hoskins; Melissa J Moore
Journal:  Trends Biochem Sci       Date:  2012-04-03       Impact factor: 13.807

5.  Now on display: a gallery of group II intron structures at different stages of catalysis.

Authors:  Marco Marcia; Srinivas Somarowthu; Anna Marie Pyle
Journal:  Mob DNA       Date:  2013-05-01
  5 in total

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