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Literature DB >> 18570869

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

Duncan J Smith¹, Charles C Query, Maria M Konarska.

Abstract

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

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Year: 2008 PMID： 18570869 PMCID： PMC2610350 DOI： 10.1016/j.molcel.2008.04.013

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

91 in total

1. The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast.

Authors: R T O'Keefe; C Norman; A J Newman
Journal: Cell Date: 1996-08-23 Impact factor: 41.582

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Journal: Proc Natl Acad Sci U S A Date: 1996-12-24 Impact factor: 11.205

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Authors: M D Chiara; R Reed
Journal: Nature Date: 1995-06-08 Impact factor: 49.962

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Authors: E J Sontheimer; J A Steitz
Journal: Science Date: 1993-12-24 Impact factor: 47.728

5. During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles.

Authors: B Bailleul
Journal: Nucleic Acids Res Date: 1996-03-15 Impact factor: 16.971

6. U4/U5/U6 snRNP recognizes the 5' splice site in the absence of U2 snRNP.

Authors: B B Konforti; M M Konarska
Journal: Genes Dev Date: 1994-08-15 Impact factor: 11.361

7. Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly.

Authors: B Charpentier; M Rosbash
Journal: RNA Date: 1996-06 Impact factor: 4.942

8. Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.

Authors: C W Smith; T T Chu; B Nadal-Ginard
Journal: Mol Cell Biol Date: 1993-08 Impact factor: 4.272

9. Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5' splice site.

Authors: C H Kim; J Abelson
Journal: RNA Date: 1996-10 Impact factor: 4.942

10. Effects of secondary structure on pre-mRNA splicing: hairpins sequestering the 5' but not the 3' splice site inhibit intron processing in Nicotiana plumbaginifolia.

Authors: H X Liu; G J Goodall; R Kole; W Filipowicz
Journal: EMBO J Date: 1995-01-16 Impact factor: 11.598

84 in total

1. CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.

Authors: Charles C Query; Maria M Konarska
Journal: RNA Date: 2012-03-08 Impact factor: 4.942

2. The RNA polymerase C-terminal domain: a new role in spliceosome assembly.

Authors: Charles J David; James L Manley
Journal: Transcription Date: 2011 Sep-Oct

3. Structure of the yeast U2/U6 snRNA complex.

Authors: Jordan E Burke; Dipali G Sashital; Xiaobing Zuo; Yun-Xing Wang; Samuel E Butcher
Journal: RNA Date: 2012-02-10 Impact factor: 4.942

4. An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing.

Authors: Natalia N Singh; Katrin Hollinger; Dhruva Bhattacharya; Ravindra N Singh
Journal: RNA Date: 2010-04-22 Impact factor: 4.942

Review 10. Structural and functional characteristics of oestrogen receptor β splice variants: Implications for the ageing brain.

Authors: C K Kim; A Torcaso; A Asimes; W C J Chung; T R Pak
Journal: J Neuroendocrinol Date: 2018-02 Impact factor: 3.627