Literature DB >> 1872919

Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol.

A L Akeson1, C W Woods, L B Mosher, C E Thomas, R L Jackson.   

Abstract

The cytokine interleukin-1, IL-1, likely plays an important role in the early stages of atherogenesis. The possible action of probucol and tocopherol on the expression and secretion of IL-1 beta was investigated using the human monocytic leukemia cell line, THP-1. Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation. Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene. The data suggest that the beneficial effects of probucol may be related to inhibition of IL-1 at an early phase of atherosclerotic plaque formation.

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Year:  1991        PMID： 1872919     DOI： 10.1016/0021-9150(91)90222-o

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  10 in total

1.  The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

Authors:  S Devaraj; D Li; I Jialal
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

2.  Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract.

Authors:  A M Amarakoon; P S Tappia; R F Grimble
Journal:  Inflamm Res       Date:  1995-07       Impact factor: 4.575

3.  Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.

Authors:  Amanda Z Zucoloto; Marília F Manchope; Larrisa Staurengo-Ferrari; José C Alves-Filho; Thiago M Cunha; Maísa M Antunes; Gustavo B Menezes; Fernando Q Cunha; Rubia Casagrande; Waldiceu A Verri
Journal:  Inflamm Res       Date:  2017-04-06       Impact factor: 4.575

4.  Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

Authors:  C P Sparrow; T W Doebber; J Olszewski; M S Wu; J Ventre; K A Stevens; Y S Chao
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808

5.  Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit.

Authors:  G A Ferns; L Forster; A Stewart-Lee; M Konneh; J Nourooz-Zadeh; E E Anggård
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

6.  Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

Authors:  G Di Minno; G Davì; M Margaglione; F Cirillo; E Grandone; G Ciabattoni; I Catalano; P Strisciuglio; G Andria; C Patrono
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

7.  Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

Authors:  S Picard; S Parthasarathy; J Fruebis; J L Witztum
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

Review 8.  Probucol.

Authors:  K D Pfuetze; C A Dujovne
Journal:  Curr Atheroscler Rep       Date:  2000-01       Impact factor: 5.967

9.  Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis.

Authors:  Hyun Joo Lee
Journal:  J Clin Med       Date:  2022-08-12       Impact factor: 4.964

10.  Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa.

Authors:  Saad Hamama; Sylvie Delanian; Virginie Monceau; Marie-Catherine Vozenin
Journal:  Fibrogenesis Tissue Repair       Date:  2012-06-06
  10 in total

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