Literature DB >> 18713257

MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases.

Y Wang1, Y Liang, Q Lu.   

Abstract

MicroRNAs (miRNAs) consist of a class of evolutionarily conserved small non-coding RNA that regulates target messenger RNAs by mechanisms such as incomplete base pairing and post-transcriptional gene silencing. Recent studies have shown that aberrant miRNA expression is a common feature of many human disorders including aging, heart diseases, cancer, autoimmune diseases and others. It seems likely that miRNA expression levels can be used as novel diagnostic markers. MiRNAs may also provide a new strategy for therapeutic interventions. In this review, we focus on recent advances in understanding how miRNA changes contribute to disease development and their potential as novel biomarkers and therapeutic targets for human diseases.

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Year:  2008        PMID： 18713257     DOI： 10.1111/j.1399-0004.2008.01075.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  39 in total

Review 1.  Epigenetic control of aging.

Authors:  Ursula Muñoz-Najar; John M Sedivy
Journal:  Antioxid Redox Signal       Date:  2010-11-22       Impact factor: 8.401

2.  Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "microprocessor" complex.

Authors:  Christopher Wostenberg; Kaycee A Quarles; Scott A Showalter
Journal:  Biochemistry       Date:  2010-11-22       Impact factor: 3.162

Review 3.  [Delirium in the elderly].

Authors:  Manfred Gogol
Journal:  Z Gerontol Geriatr       Date:  2008-10-30       Impact factor: 1.281

4.  MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development.

Authors:  Pengcui Li; Xiaochun Wei; Yingjie Guan; Qian Chen; Tingcun Zhao; Changqi Sun; Lei Wei
Journal:  FASEB J       Date:  2014-05-23       Impact factor: 5.191

5.  Extensive miRNA expression analysis in craniopharyngiomas.

Authors:  Jill Samis; Elio F Vanin; Simone Treiger Sredni; Maria de Fátima de Bonaldo; Fabricio F Costa; Tadanori Tomita; Reema Habiby; Donald Zimmerman; Marcelo B Soares
Journal:  Childs Nerv Syst       Date:  2016-06-07       Impact factor: 1.475

Review 6.  MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases.

Authors:  Julianna K Edwards; Renata Pasqualini; Wadih Arap; George A Calin
Journal:  J Cardiovasc Transl Res       Date:  2010-05-05       Impact factor: 4.132

Review 7.  The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.

Authors:  Yunsheng Liang; Christopher Chang; Qianjin Lu
Journal:  Clin Rev Allergy Immunol       Date:  2016-12       Impact factor: 8.667

8.  Cross-platform analysis of global microRNA expression technologies.

Authors:  Carole L Yauk; Andrea Rowan-Carroll; John Dh Stead; Andrew Williams
Journal:  BMC Genomics       Date:  2010-05-26       Impact factor: 3.969

Review 9.  Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials.

Authors:  Sha Zhao; Hai Long; Qianjin Lu
Journal:  Clin Rev Allergy Immunol       Date:  2010-08       Impact factor: 8.667

10.  Long noncoding RNA LINC00657 enhances the malignancy of pancreatic ductal adenocarcinoma by acting as a competing endogenous RNA on microRNA-433 to increase PAK4 expression.

Authors:  Shasha Bi; Yan Wang; Hu Feng; Qingchang Li
Journal:  Cell Cycle       Date:  2020-03-01       Impact factor: 4.534
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