Literature DB >> 19639427

Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials.

Sha Zhao1, Hai Long, Qianjin Lu.   

Abstract

System lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that cause widespread tissue damage. The underlying etiology remains largely unknown. Aberrant epigenetics plays essential roles in the pathogenesis of SLE. This review explores the links between DNA methylation, histone modifications, and miRNAs in SLE and highlights how these factors may interact in SLE pathogenesis. We also discuss how furthering our knowledge of epigenetics in lupus provides hope for finding new diagnostic and prognostic biomarkers and novel therapeutic targets and strategies.

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Year:  2010        PMID： 19639427     DOI： 10.1007/s12016-009-8165-7

Source DB:  PubMed          Journal:  Clin Rev Allergy Immunol        ISSN： 1080-0549            Impact factor:   8.667


  70 in total

1.  DNA methyltransferase Dnmt1 associates with histone deacetylase activity.

Authors:  F Fuks; W A Burgers; A Brehm; L Hughes-Davies; T Kouzarides
Journal:  Nat Genet       Date:  2000-01       Impact factor: 38.330

2.  The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

Authors:  Francois Fuks; Paul J Hurd; Daniel Wolf; Xinsheng Nan; Adrian P Bird; Tony Kouzarides
Journal:  J Biol Chem       Date:  2002-11-09       Impact factor: 5.157

3.  miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.

Authors:  Beiyan Zhou; Stephanie Wang; Christine Mayr; David P Bartel; Harvey F Lodish
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-16       Impact factor: 11.205

4.  NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.

Authors:  Konstantin D Taganov; Mark P Boldin; Kuang-Jung Chang; David Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-02       Impact factor: 11.205

5.  Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

Authors:  B Richardson; L Scheinbart; J Strahler; L Gross; S Hanash; M Johnson
Journal:  Arthritis Rheum       Date:  1990-11

6.  MicroRNA-155 function in B Cells.

Authors:  Kathryn Calame
Journal:  Immunity       Date:  2007-12       Impact factor: 31.745

Review 7.  Epigenetic regulation and the pathogenesis of systemic lupus erythematosus.

Authors:  Yujun Pan; Amr H Sawalha
Journal:  Transl Res       Date:  2008-11-14       Impact factor: 7.012

8.  Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

Authors:  E Cornacchia; J Golbus; J Maybaum; J Strahler; S Hanash; B Richardson
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

9.  Abnormal histone modification patterns in lupus CD4+ T cells.

Authors:  Nan Hu; Xiangning Qiu; Yongqi Luo; Jun Yuan; Yaping Li; Wenzhi Lei; Guiying Zhang; Ying Zhou; Yuwen Su; Qianjin Lu
Journal:  J Rheumatol       Date:  2008-04-01       Impact factor: 4.666

Review 10.  Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease.

Authors:  Glinda S Cooper; Kathleen M Gilbert; Eric L Greidinger; Judith A James; Jean C Pfau; Leslie Reinlib; Bruce C Richardson; Noel R Rose
Journal:  Environ Health Perspect       Date:  2008-06       Impact factor: 9.031
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  19 in total

Review 1.  The therapeutic potential of epigenetics in autoimmune diseases.

Authors:  Maria De Santis; Carlo Selmi
Journal:  Clin Rev Allergy Immunol       Date:  2012-02       Impact factor: 8.667

2.  Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.

Authors:  Paula S Ramos; Elisabeth E Brown; Robert P Kimberly; Carl D Langefeld
Journal:  Semin Nephrol       Date:  2010-03       Impact factor: 5.299

3.  CREMα suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.

Authors:  Debjani Ghosh; Katalin Kis-Toth; Yuang-Taung Juang; George C Tsokos
Journal:  Arthritis Rheum       Date:  2012-03

Review 4.  Characters, functions and clinical perspectives of long non-coding RNAs.

Authors:  Ruifang Wu; Yuwen Su; Haijing Wu; Yong Dai; Ming Zhao; Qianjin Lu
Journal:  Mol Genet Genomics       Date:  2016-02-17       Impact factor: 3.291

Review 5.  CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases.

Authors:  Yixin Tan; Ming Zhao; Bo Xiang; Christopher Chang; Qianjin Lu
Journal:  Clin Rev Allergy Immunol       Date:  2016-02       Impact factor: 8.667

6.  Cutting-edge issues in organ-specific autoimmunity.

Authors:  M Eric Gershwin; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2011-10       Impact factor: 8.667

Review 7.  The autoimmune side of heart and lung diseases.

Authors:  Nancy Agmon-Levin; Carlo Selmi
Journal:  Clin Rev Allergy Immunol       Date:  2013-02       Impact factor: 8.667

8.  Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus.

Authors:  Kenneth L Wiley; Edward Treadwell; Kayihura Manigaba; Beverly Word; Beverly D Lyn-Cook
Journal:  J Clin Immunol       Date:  2012-10-09       Impact factor: 8.317

9.  The future of autoimmunity.

Authors:  Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2012-04       Impact factor: 8.667

10.  Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients.

Authors:  Ge Yang; Daoquan Wu; Guang Zeng; Ou Jiang; Pingzong Yuan; Shenjie Huang; Jing Zhu; Jie Tian; Yaguang Weng; Zhihua Rao
Journal:  Int J Clin Exp Pathol       Date:  2015-08-01
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