Literature DB >> 1870093

Localisation of the MRX3 gene for non-specific X linked mental retardation.

A Gedeon1, B Kerr, J Mulley, G Turner.   

Abstract

A family is described with five affected males segregating a new gene for non-specific X linked mental retardation (MRX). Linkage analysis localised the gene at Xq28-qter. The maximum lod score was 2.89 with DXS52 (St14) at theta = 0.0. A recombinant was observed with DXS304 (U6.2) defining the proximal limit to the localisation. No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRX1 and MRX2. This delineates the third gene for non-specific X linked mental retardation, MRX3.

Entities:  

Mesh：

Year:  1991        PMID： 1870093      PMCID： PMC1016900          DOI： 10.1136/jmg.28.6.372

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  18 in total

1.  A computer program for linkage analysis of general human pedigrees.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1976-09       Impact factor: 11.025

2.  A non-syndromal form of X-linked mental retardation (XLMR) is linked to DXS14.

Authors:  G K Suthers; G Turner; J C Mulley
Journal:  Am J Med Genet       Date:  1988 May-Jun

3.  Localization of the gene for a syndrome of X-linked skeletal dysplasia and mental retardation to Xq27-qter.

Authors:  S R Dlouhy; J C Christian; J L Haines; P M Conneally; M E Hodes
Journal:  Hum Genet       Date:  1987-02       Impact factor: 4.132

4.  X-linked mental retardation and verbal disability.

Authors:  R G Lehrke
Journal:  Birth Defects Orig Artic Ser       Date:  1974

5.  X-linked mental retardation.

Authors:  G Turner; B Turner
Journal:  J Med Genet       Date:  1974-06       Impact factor: 6.318

6.  Genetic counseling in rare syndromes: a resampling method for determining an approximate confidence interval for gene location with linkage data from a single pedigree.

Authors:  G K Suthers; S R Wilson
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025

7.  Linkage and genetic counselling for the fragile X using DNA probes 52A, F9, DX13, and ST14.

Authors:  J C Mulley; A K Gedeon; K A Thorn; L J Bates; G R Sutherland
Journal:  Am J Med Genet       Date:  1987-06

8.  Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Am J Hum Genet       Date:  1985-05       Impact factor: 11.025

9.  Linkage studies of X-linked recessive spastic paraplegia using DNA probes.

Authors:  S Kenwrick; V Ionasescu; G Ionasescu; C Searby; A King; M Dubowitz; K E Davies
Journal:  Hum Genet       Date:  1986-07       Impact factor: 4.132

10.  Physical mapping of new DNA probes near the fragile X mutation (FRAXA) by using a panel of cell lines.

Authors:  G K Suthers; V J Hyland; D F Callen; I Oberle; M Rocchi; N S Thomas; C P Morris; C E Schwartz; M Schmidt; H H Ropers
Journal:  Am J Hum Genet       Date:  1990-08       Impact factor: 11.025
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  12 in total

1.  A new X linked recessive syndrome of mental retardation and mild dysmorphism maps to Xq28.

Authors:  G S Pai; B Hane; M Joseph; R Nelson; L S Hammond; J F Arena; H A Lubs; R E Stevenson; C E Schwartz
Journal:  J Med Genet       Date:  1997-07       Impact factor: 6.318

2.  Linkage to Xq28 in a family with nonspecific X-linked mental retardation.

Authors:  A M Nordström; M Penttinen; H von Koskull
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

3.  PPM-X: a new X-linked mental retardation syndrome with psychosis, pyramidal signs, and macroorchidism maps to Xq28.

Authors:  S Lindsay; M Splitt; S Edney; T P Berney; S J Knight; K E Davies; O O'Brien; M Gale; J Burn
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

Review 4.  Non-specific X linked mental retardation.

Authors:  B Kerr; G Turner; J Mulley; A Gedeon; M Partington
Journal:  J Med Genet       Date:  1991-06       Impact factor: 6.318

5.  A gene for dominant nonspecific X-linked mental retardation is located in Xq28.

Authors:  V des Portes; P Billuart; A Carrié; L Bachner; T Bienvenu; M C Vinet; C Beldjord; G Ponsot; A Kahn; J Boué; J Chelly
Journal:  Am J Hum Genet       Date:  1997-04       Impact factor: 11.025

6.  Identification of a 650 kb duplication at the X chromosome breakpoint in a patient with 46,X,t(X;8)(q28;q12) and non-syndromic mental retardation.

Authors:  J J Cox; S T Holden; S Dee; J I Burbridge; F L Raymond
Journal:  J Med Genet       Date:  2003-03       Impact factor: 6.318

7.  Localisation of a new gene for non-specific mental retardation to Xq22-q26 (MRX35).

Authors:  X X Gu; R Decorte; P Marynen; J P Fryns; J J Cassiman; P Raeymaekers
Journal:  J Med Genet       Date:  1996-01       Impact factor: 6.318

8.  Mapping of a gene for non-specific X linked mental retardation: evidence for linkage to chromosomal region Xp21.1-Xp22.3.

Authors:  L Kozák; P Chiurazzi; M Genuardi; M G Pomponi; M Zollino; G Neri
Journal:  J Med Genet       Date:  1993-10       Impact factor: 6.318

9.  A noncoding, regulatory mutation implicates HCFC1 in nonsyndromic intellectual disability.

Authors:  Lingli Huang; Lachlan A Jolly; Saffron Willis-Owen; Alison Gardner; Raman Kumar; Evelyn Douglas; Cheryl Shoubridge; Dagmar Wieczorek; Andreas Tzschach; Monika Cohen; Anna Hackett; Michael Field; Guy Froyen; Hao Hu; Stefan A Haas; Hans-Hilger Ropers; Vera M Kalscheuer; Mark A Corbett; Jozef Gecz
Journal:  Am J Hum Genet       Date:  2012-09-20       Impact factor: 11.025

10.  Molecular cloning and characterization of a novel mouse actin-binding protein Zfp185.

Authors:  Na Wang; Quanhui Zheng; Jin-San Zhang; Yong Zhao
Journal:  J Mol Histol       Date:  2008-02-01       Impact factor: 2.611
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