| Literature DB >> 18691963 |
Daniel E Golden1, Vincent R Gerbasi, Erik J Sontheimer.
Abstract
Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.Entities:
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Year: 2008 PMID: 18691963 PMCID: PMC2675693 DOI: 10.1016/j.molcel.2008.07.008
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970