BACKGROUND: A graft-versus-lymphoma effect against diffuse large B-cell lymphoma (DLBCL) is inferred by sustained relapse-free survival after allogeneic stem-cell transplantation; however, there are limited data on a direct graft-versus-lymphoma effect against DLBCL following immunotherapeutic intervention by either withdrawal of immunosuppression or donor lymphocyte infusion (DLI). MATERIALS AND METHODS: An analysis was carried out to determine whether a direct graft-versus-lymphoma effect exists against DLBCL. The analysis was restricted to patients with DLBCL, who were either not in complete remission at day +100 after allogeneic stem-cell transplantation or subsequently relapsed beyond this time point. RESULTS: Fifteen patients were identified as either not in complete remission (n = 13) at their day +100 evaluation or subsequently relapsed (n = 2) and were assessed for subsequent responses after withdrawal of immunosuppression or DLI. Eleven patients were treated with either withdrawal of immunosuppression (n = 10) or a DLI (n = 1) alone; four patients received chemotherapy with DLI to reduce tumor bulk. Nine (60%) patients subsequently responded (complete = 8, partial = 1). Six responses occurred after withdrawal of immunosuppression alone. Six patients are alive (range 42-83+ months) in complete remission without further treatment. CONCLUSION: The demonstration of sustained complete remission following immunotherapeutic intervention provides direct evidence of a graft-versus-lymphoma effect against DLBCL.
BACKGROUND: A graft-versus-lymphoma effect against diffuse large B-cell lymphoma (DLBCL) is inferred by sustained relapse-free survival after allogeneic stem-cell transplantation; however, there are limited data on a direct graft-versus-lymphoma effect against DLBCL following immunotherapeutic intervention by either withdrawal of immunosuppression or donor lymphocyte infusion (DLI). MATERIALS AND METHODS: An analysis was carried out to determine whether a direct graft-versus-lymphoma effect exists against DLBCL. The analysis was restricted to patients with DLBCL, who were either not in complete remission at day +100 after allogeneic stem-cell transplantation or subsequently relapsed beyond this time point. RESULTS: Fifteen patients were identified as either not in complete remission (n = 13) at their day +100 evaluation or subsequently relapsed (n = 2) and were assessed for subsequent responses after withdrawal of immunosuppression or DLI. Eleven patients were treated with either withdrawal of immunosuppression (n = 10) or a DLI (n = 1) alone; four patients received chemotherapy with DLI to reduce tumor bulk. Nine (60%) patients subsequently responded (complete = 8, partial = 1). Six responses occurred after withdrawal of immunosuppression alone. Six patients are alive (range 42-83+ months) in complete remission without further treatment. CONCLUSION: The demonstration of sustained complete remission following immunotherapeutic intervention provides direct evidence of a graft-versus-lymphoma effect against DLBCL.
Authors: R I Fisher; E R Gaynor; S Dahlberg; M M Oken; T M Grogan; E M Mize; J H Glick; C A Coltman; T P Miller Journal: N Engl J Med Date: 1993-04-08 Impact factor: 91.245
Authors: T Philip; C Guglielmi; A Hagenbeek; R Somers; H Van der Lelie; D Bron; P Sonneveld; C Gisselbrecht; J Y Cahn; J L Harousseau Journal: N Engl J Med Date: 1995-12-07 Impact factor: 91.245
Authors: C Haioun; E Lepage; C Gisselbrecht; Y Bastion; B Coiffier; P Brice; A Bosly; B Dupriez; C Nouvel; H Tilly; P Lederlin; P Biron; J Brière; P Gaulard; F Reyes Journal: J Clin Oncol Date: 1997-03 Impact factor: 44.544
Authors: Maricer P Escalón; Richard E Champlin; Rima M Saliba; Sandra A Acholonu; Chitra Hosing; Luis Fayad; Sergio Giralt; Naoto T Ueno; Farzaneh Maadani; Barbara Pro; Michele Donato; Peter McLaughlin; Issa F Khouri Journal: J Clin Oncol Date: 2004-06-15 Impact factor: 44.544
Authors: V Ratanatharathorn; J Uberti; C Karanes; E Abella; L G Lum; F Momin; G Cummings; L L Sensenbrenner Journal: Blood Date: 1994-08-15 Impact factor: 22.113
Authors: A-K Zoellner; S Fritsch; D Prevalsek; N Engel; M Hubmann; R Reibke; C T Rieger; J C Hellmuth; M Haas; F Mumm; T Herold; G Ledderose; W Hiddemann; M Dreyling; A Hausmann; J Tischer Journal: Bone Marrow Transplant Date: 2015-02-02 Impact factor: 5.483
Authors: Timothy S Fenske; Kwang W Ahn; Tara M Graff; Alyssa DiGilio; Qaiser Bashir; Rammurti T Kamble; Ernesto Ayala; Ulrike Bacher; Jonathan E Brammer; Mitchell Cairo; Andy Chen; Yi-Bin Chen; Saurabh Chhabra; Anita D'Souza; Umar Farooq; Cesar Freytes; Siddhartha Ganguly; Mark Hertzberg; David Inwards; Samantha Jaglowski; Mohamed A Kharfan-Dabaja; Hillard M Lazarus; Sunita Nathan; Attaphol Pawarode; Miguel-Angel Perales; Nishitha Reddy; Sachiko Seo; Anna Sureda; Sonali M Smith; Mehdi Hamadani Journal: Br J Haematol Date: 2016-03-15 Impact factor: 6.998
Authors: E Van Den Neste; N Schmitz; N Mounier; D Gill; D Linch; M Trneny; R Bouadballah; J Radford; M Bargetzi; V Ribrag; U Dührsen; D Ma; J Briere; C Thieblemont; E Bachy; C H Moskowitz; B Glass; C Gisselbrecht Journal: Bone Marrow Transplant Date: 2016-09-19 Impact factor: 5.483
Authors: James N Kochenderfer; Mark E Dudley; Robert O Carpenter; Sadik H Kassim; Jeremy J Rose; William G Telford; Frances T Hakim; David C Halverson; Daniel H Fowler; Nancy M Hardy; Anthony R Mato; Dennis D Hickstein; Juan C Gea-Banacloche; Steven Z Pavletic; Claude Sportes; Irina Maric; Steven A Feldman; Brenna G Hansen; Jennifer S Wilder; Bazetta Blacklock-Schuver; Bipulendu Jena; Michael R Bishop; Ronald E Gress; Steven A Rosenberg Journal: Blood Date: 2013-09-20 Impact factor: 22.113
Authors: M A Kharfan-Dabaja; N El-Jurdi; E Ayala; A S Kanate; B N Savani; M Hamadani Journal: Bone Marrow Transplant Date: 2017-04-03 Impact factor: 5.483
Authors: Timothy S Fenske; Mehdi Hamadani; Jonathon B Cohen; Luciano J Costa; Brad S Kahl; Andrew M Evens; Paul A Hamlin; Hillard M Lazarus; Effie Petersdorf; Christopher Bredeson Journal: Biol Blood Marrow Transplant Date: 2016-04-27 Impact factor: 5.742
Authors: E Klyuchnikov; U Bacher; T Kroll; T C Shea; H M Lazarus; C Bredeson; T S Fenske Journal: Bone Marrow Transplant Date: 2013-05-27 Impact factor: 5.483
Authors: Ulrike Bacher; Evgeny Klyuchnikov; Jennifer Le-Rademacher; Jeanette Carreras; Philippe Armand; Michael R Bishop; Christopher N Bredeson; Mitchell S Cairo; Timothy S Fenske; Cesar O Freytes; Robert Peter Gale; John Gibson; Luis M Isola; David J Inwards; Ginna G Laport; Hillard M Lazarus; Richard T Maziarz; Peter H Wiernik; Harry C Schouten; Shimon Slavin; Sonali M Smith; Julie M Vose; Edmund K Waller; Parameswaran N Hari Journal: Blood Date: 2012-09-24 Impact factor: 22.113