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Literature DB >> 18671435

Solution phase synthesis of a diverse library of highly substituted isoxazoles.

Jesse P Waldo¹, Saurabh Mehta, Benjamin Neuenswander, Gerald H Lushington, Richard C Larock.

Abstract

The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.

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Year: 2008 PMID： 18671435 PMCID： PMC3750120 DOI： 10.1021/cc800055x

Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766

15 in total

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