Literature DB >> 8642551

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

M Rowley1, H B Broughton, I Collins, R Baker, F Emms, R Marwood, S Patel, S Patel, C I Ragan, S B Freedman, P D Leeson.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8642551     DOI： 10.1021/jm960072u

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  8 in total

1.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

2.  Solution phase synthesis of a diverse library of highly substituted isoxazoles.

Authors:  Jesse P Waldo; Saurabh Mehta; Benjamin Neuenswander; Gerald H Lushington; Richard C Larock
Journal:  J Comb Chem       Date:  2008-08-01

3.  Effects of dopamine on ion transport across the rat distal colon.

Authors:  Abed A Al-Jahmany; Gerhard Schultheiss; Martin Diener
Journal:  Pflugers Arch       Date:  2004-07-03       Impact factor: 3.657

4.  An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.

Authors:  Ivan T Lee; Shiuhwei Chen; John A Schetz
Journal:  Eur J Pharmacol       Date:  2007-10-02       Impact factor: 4.432

5.  The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib.

Authors:  Jesse P Waldo; Richard C Larock
Journal:  J Org Chem       Date:  2007-11-03       Impact factor: 4.354

6.  Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling.

Authors:  Jessica L Smith; David A Stein; David Shum; Matthew A Fischer; Constantin Radu; Bhavneet Bhinder; Hakim Djaballah; Jay A Nelson; Klaus Früh; Alec J Hirsch
Journal:  J Virol       Date:  2014-03-05       Impact factor: 5.103

7.  Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex.

Authors:  Xun Wang; Ping Zhong; Zhenglin Gu; Zhen Yan
Journal:  J Neurosci       Date:  2003-10-29       Impact factor: 6.167

8.  Ultra-large library docking for discovering new chemotypes.

Authors:  Jiankun Lyu; Sheng Wang; Trent E Balius; Isha Singh; Anat Levit; Yurii S Moroz; Matthew J O'Meara; Tao Che; Enkhjargal Algaa; Kateryna Tolmachova; Andrey A Tolmachev; Brian K Shoichet; Bryan L Roth; John J Irwin
Journal:  Nature       Date:  2019-02-06       Impact factor: 49.962
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.