| Literature DB >> 18666772 |
Muhammad Alimuddin1, Daniel Grant, Daryl Bulloch, Noelle Lee, Martin Peacock, Russell Dahl.
Abstract
A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2) = 0.994). The developed methodology is amenable to automation, enabling high-throughput determination of large compound collections.Mesh：
Year: 2008 PMID： 18666772 DOI： 10.1021/jm8005228
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446