Literature DB >> 18657537

Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.

Christopher A McDevitt1, Chitra A Shintre, J Günter Grossmann, Naomi L Pollock, Stephen M Prince, Richard Callaghan, Robert C Ford.   

Abstract

P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.

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Year:  2008        PMID： 18657537     DOI： 10.1016/j.febslet.2008.07.022

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  The ATP-binding cassette family: a structural perspective.

Authors:  Veronica Kos; Robert Curtis Ford
Journal:  Cell Mol Life Sci       Date:  2009-06-21       Impact factor: 9.261

2.  Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs.

Authors:  T K Ritchie; Y V Grinkova; T H Bayburt; I G Denisov; J K Zolnerciks; W M Atkins; S G Sligar
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

3.  Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

Authors:  Thomas Stockner; Sjoerd J de Vries; Alexandre M J J Bonvin; Gerhard F Ecker; Peter Chiba
Journal:  FEBS J       Date:  2009-02       Impact factor: 5.542

Review 4.  Cystic fibrosis transmembrane conductance regulator (ABCC7) structure.

Authors:  John F Hunt; Chi Wang; Robert C Ford
Journal:  Cold Spring Harb Perspect Med       Date:  2013-02-01       Impact factor: 6.915

5.  The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate.

Authors:  Mark F Rosenberg; Liam P O'Ryan; Guy Hughes; Zhefeng Zhao; Luba A Aleksandrov; John R Riordan; Robert C Ford
Journal:  J Biol Chem       Date:  2011-09-19       Impact factor: 5.157

6.  Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.

Authors:  John G Wise
Journal:  Biochemistry       Date:  2012-06-12       Impact factor: 3.162

7.  Cell-imprinted substrates: in search of nanotopographical fingerprints that guide stem cell differentiation.

Authors:  Khorshid Kamguyan; Saeed Zajforoushan Moghaddam; Abolfazl Nazbar; Seyyed Mohammad Amin Haramshahi; Shiva Taheri; Shahin Bonakdar; Esben Thormann
Journal:  Nanoscale Adv       Date:  2020-12-08

8.  Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein.

Authors:  Sarah Rottet; Shagufta Iqbal; Paul A Beales; Anran Lin; Jiwon Lee; Melanie Rug; Colin Scott; Richard Callaghan
Journal:  Polymers (Basel)       Date:  2020-05-03       Impact factor: 4.329

9.  Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4.

Authors:  David Hardy; Roslyn M Bill; Anass Jawhari; Alice J Rothnie
Journal:  SLAS Discov       Date:  2019-08-05       Impact factor: 3.341
  9 in total

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