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Literature DB >> 18654571

Genome-wide association studies: a new window into immune-mediated diseases.

Abstract

Given the recent explosion of genetic discoveries, 2007 is becoming known to human geneticists as the year of genome-wide association studies. In fact, more genetic risk factors for common diseases were identified in this one year than had been collectively reported before 2007. In particular, 2007 witnessed the discovery of many genes that influence susceptibility to individual immune-mediated diseases, as well as other genes that are associated with susceptibility to more than one disease. Although much work remains to be done, in this Review we discuss what effect these studies are having on our understanding of disease pathogenesis and their potential impact on future immunology studies.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2008 PMID： 18654571 PMCID： PMC2750781 DOI： 10.1038/nri2361

Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106

95 in total

1. An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

Authors: Jenson Lim; Agnès Wiedemann; George Tzircotis; Susan J Monkley; David R Critchley; Emmanuelle Caron
Journal: Mol Biol Cell Date: 2007-01-03 Impact factor: 4.138

2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Authors: Richard H Duerr; Kent D Taylor; Steven R Brant; John D Rioux; Mark S Silverberg; Mark J Daly; A Hillary Steinhart; Clara Abraham; Miguel Regueiro; Anne Griffiths; Themistocles Dassopoulos; Alain Bitton; Huiying Yang; Stephan Targan; Lisa Wu Datta; Emily O Kistner; L Philip Schumm; Annette T Lee; Peter K Gregersen; M Michael Barmada; Jerome I Rotter; Dan L Nicolae; Judy H Cho
Journal: Science Date: 2006-10-26 Impact factor: 47.728

Review 3. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.

Authors: Robert A Kastelein; Christopher A Hunter; Daniel J Cua
Journal: Annu Rev Immunol Date: 2007 Impact factor: 28.527

4. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Authors: John D Rioux; Ramnik J Xavier; Kent D Taylor; Mark S Silverberg; Philippe Goyette; Alan Huett; Todd Green; Petric Kuballa; M Michael Barmada; Lisa Wu Datta; Yin Yao Shugart; Anne M Griffiths; Stephan R Targan; Andrew F Ippoliti; Edmond-Jean Bernard; Ling Mei; Dan L Nicolae; Miguel Regueiro; L Philip Schumm; A Hillary Steinhart; Jerome I Rotter; Richard H Duerr; Judy H Cho; Mark J Daly; Steven R Brant
Journal: Nat Genet Date: 2007-04-15 Impact factor: 38.330

5. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

Authors: Michele Cargill; Steven J Schrodi; Monica Chang; Veronica E Garcia; Rhonda Brandon; Kristina P Callis; Nori Matsunami; Kristin G Ardlie; Daniel Civello; Joseph J Catanese; Diane U Leong; Jackie M Panko; Linda B McAllister; Christopher B Hansen; Jason Papenfuss; Stephen M Prescott; Thomas J White; Mark F Leppert; Gerald G Krueger; Ann B Begovich
Journal: Am J Hum Genet Date: 2006-12-21 Impact factor: 11.025

6. A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Authors: Tai Wai Yeo; Philip L De Jager; Simon G Gregory; Lisa F Barcellos; Amie Walton; An Goris; Chiara Fenoglio; Maria Ban; Craig J Taylor; Reyna S Goodman; Emily Walsh; Cara S Wolfish; Roger Horton; James Traherne; Stephan Beck; John Trowsdale; Stacy J Caillier; Adrian J Ivinson; Todd Green; Susan Pobywajlo; Eric S Lander; Margaret A Pericak-Vance; Jonathan L Haines; Mark J Daly; Jorge R Oksenberg; Stephen L Hauser; Alastair Compston; David A Hafler; John D Rioux; Stephen Sawcer
Journal: Ann Neurol Date: 2007-03 Impact factor: 10.422

7. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

Authors: Robert R Graham; Chieko Kyogoku; Snaevar Sigurdsson; Irina A Vlasova; Leela R L Davies; Emily C Baechler; Robert M Plenge; Thearith Koeuth; Ward A Ortmann; Geoffrey Hom; Jason W Bauer; Clarence Gillett; Noel Burtt; Deborah S Cunninghame Graham; Robert Onofrio; Michelle Petri; Iva Gunnarsson; Elisabet Svenungsson; Lars Rönnblom; Gunnel Nordmark; Peter K Gregersen; Kathy Moser; Patrick M Gaffney; Lindsey A Criswell; Timothy J Vyse; Ann-Christine Syvänen; Paul R Bohjanen; Mark J Daly; Timothy W Behrens; David Altshuler
Journal: Proc Natl Acad Sci U S A Date: 2007-04-05 Impact factor: 11.205

8. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Authors: Jochen Hampe; Andre Franke; Philip Rosenstiel; Andreas Till; Markus Teuber; Klaus Huse; Mario Albrecht; Gabriele Mayr; Francisco M De La Vega; Jason Briggs; Simone Günther; Natalie J Prescott; Clive M Onnie; Robert Häsler; Bence Sipos; Ulrich R Fölsch; Thomas Lengauer; Matthias Platzer; Christopher G Mathew; Michael Krawczak; Stefan Schreiber
Journal: Nat Genet Date: 2006-12-31 Impact factor: 38.330

9. A critical role for the autophagy gene Atg5 in T cell survival and proliferation.

Authors: Heather H Pua; Ivan Dzhagalov; Mariana Chuck; Noboru Mizushima; You-Wen He
Journal: J Exp Med Date: 2006-12-26 Impact factor: 14.307

10. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

Authors: Oliver J Brand; Christopher E Lowe; Joanne M Heward; Jayne A Franklyn; Jason D Cooper; John A Todd; Stephen C L Gough
Journal: Clin Endocrinol (Oxf) Date: 2007-04 Impact factor: 3.478

44 in total

1. LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Authors: Agnès Gardet; Yair Benita; Chun Li; Bruce E Sands; Isabel Ballester; Christine Stevens; Joshua R Korzenik; John D Rioux; Mark J Daly; Ramnik J Xavier; Daniel K Podolsky
Journal: J Immunol Date: 2010-10-04 Impact factor: 5.422

Review 2. Multiple sclerosis.

Authors: Alyssa Nylander; David A Hafler
Journal: J Clin Invest Date: 2012-04-02 Impact factor: 14.808

Review 10. The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

Authors: Emma Ahlqvist; Malin Hultqvist; Rikard Holmdahl
Journal: Arthritis Res Ther Date: 2009-05-19 Impact factor: 5.156

Genome-wide association studies: a new window into immune-mediated diseases.

1. An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Review 3. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.

4. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

5. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

6. A second major histocompatibility complex susceptibility locus for multiple sclerosis.

7. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

8. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

9. A critical role for the autophagy gene Atg5 in T cell survival and proliferation.

10. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

1. LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Review 2. Multiple sclerosis.

Review 3. Integrative systems biology and networks in autophagy.

Review 4. Personalized medicine: understanding probabilities and managing expectations.

Review 5. Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Review 6. Epigenetic alterations in inflammatory bowel disease and cancer.

Review 7. Gene-environment interactions in chronic inflammatory disease.

Review 8. Janus kinases: an ideal target for the treatment of autoimmune diseases.

Review 9. Human genetic variation and its contribution to complex traits.

Review 10. The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.