BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth. AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults. METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children. RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index. CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.
BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with humanobesity and growth. AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults. METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children. RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index. CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.
Authors: Treva Rice; Yvon C Chagnon; Louis Pérusse; Ingrid B Borecki; Olavi Ukkola; Tuomo Rankinen; Jacques Gagnon; Arthur S Leon; James S Skinner; Jack H Wilmore; Claude Bouchard; D C Rao Journal: Diabetes Date: 2002-03 Impact factor: 9.461
Authors: G C Johnson; L Esposito; B J Barratt; A N Smith; J Heward; G Di Genova; H Ueda; H J Cordell; I A Eaves; F Dudbridge; R C Twells; F Payne; W Hughes; S Nutland; H Stevens; P Carr; E Tuomilehto-Wolf; J Tuomilehto; S C Gough; D G Clayton; J A Todd Journal: Nat Genet Date: 2001-10 Impact factor: 38.330
Authors: N Vionnet; El H Hani; S Dupont; S Gallina; S Francke; S Dotte; F De Matos; E Durand; F Leprêtre; C Lecoeur; P Gallina; L Zekiri; C Dina; P Froguel Journal: Am J Hum Genet Date: 2000-11-06 Impact factor: 11.025
Authors: Sharmilee Gnanapavan; Blerina Kola; Stephen A Bustin; Damian G Morris; Patrick McGee; Peter Fairclough; Satya Bhattacharya; Robert Carpenter; Ashley B Grossman; Márta Korbonits Journal: J Clin Endocrinol Metab Date: 2002-06 Impact factor: 5.958
Authors: Hai-Jun Wang; Frank Geller; Astrid Dempfle; Nadine Schäuble; Susann Friedel; Peter Lichtner; Francisco Fontenla-Horro; Stefan Wudy; Sandra Hagemann; Ludwig Gortner; Klaus Huse; Helmut Remschmidt; Thomas Bettecken; Thomas Meitinger; Helmut Schäfer; Johannes Hebebrand; Anke Hinney Journal: J Clin Endocrinol Metab Date: 2004-01 Impact factor: 5.958