Literature DB >> 18642835

Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

Simon Giroux1, Axel Bethke, Nicole Fielenbach, Adam Antebi, E J Corey.   

Abstract

Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

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Year:  2008        PMID： 18642835      PMCID： PMC2659505          DOI： 10.1021/ol801425v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegans.

Authors:  Simon Giroux; E J Corey
Journal:  J Am Chem Soc       Date:  2007-07-21       Impact factor: 15.419

2.  An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol.

Authors:  Simon Giroux; E J Corey
Journal:  Org Lett       Date:  2008-02-05       Impact factor: 6.005

3.  Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

Authors:  Veerle Rottiers; Daniel L Motola; Birgit Gerisch; Carolyn L Cummins; Kiyoji Nishiwaki; David J Mangelsdorf; Adam Antebi
Journal:  Dev Cell       Date:  2006-03-23       Impact factor: 12.270

4.  A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.

Authors:  Birgit Gerisch; Veerle Rottiers; Dongling Li; Daniel L Motola; Carolyn L Cummins; Hans Lehrach; David J Mangelsdorf; Adam Antebi
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-14       Impact factor: 11.205

5.  Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

Authors:  Daniel L Motola; Carolyn L Cummins; Veerle Rottiers; Kamalesh K Sharma; Tingting Li; Yong Li; Kelly Suino-Powell; H Eric Xu; Richard J Auchus; Adam Antebi; David J Mangelsdorf
Journal:  Cell       Date:  2006-03-09       Impact factor: 41.582
  5 in total
  3 in total

1.  A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.

Authors:  Joshua C Judkins; Parag Mahanti; Jacob B Hoffman; Isaiah Yim; Adam Antebi; Frank C Schroeder
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-22       Impact factor: 15.336

2.  Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.

Authors:  Kamalesh K Sharma; Zhu Wang; Daniel L Motola; Carolyn L Cummins; David J Mangelsdorf; Richard J Auchus
Journal:  Mol Endocrinol       Date:  2009-02-05

3.  Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.

Authors:  Kathleen J Dumas; Chunfang Guo; Hung-Jen Shih; Patrick J Hu
Journal:  G3 (Bethesda)       Date:  2013-05-20       Impact factor: 3.154
  3 in total

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