Literature DB >> 18247628

An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol.

Simon Giroux1, E J Corey.   

Abstract

A direct and stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol has been developed.

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Year:  2008        PMID： 18247628     DOI： 10.1021/ol702936f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.

Authors:  Joshua C Judkins; Parag Mahanti; Jacob B Hoffman; Isaiah Yim; Adam Antebi; Frank C Schroeder
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-22       Impact factor: 15.336

2.  Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

Authors:  Simon Giroux; Axel Bethke; Nicole Fielenbach; Adam Antebi; E J Corey
Journal:  Org Lett       Date:  2008-07-19       Impact factor: 6.005

3.  Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.

Authors:  Kamalesh K Sharma; Zhu Wang; Daniel L Motola; Carolyn L Cummins; David J Mangelsdorf; Richard J Auchus
Journal:  Mol Endocrinol       Date:  2009-02-05

Review 4.  Structure and Biological Activity of Ergostane-Type Steroids from Fungi.

Authors:  Vladimir N Zhabinskii; Pavel Drasar; Vladimir A Khripach
Journal:  Molecules       Date:  2022-03-24       Impact factor: 4.411
  4 in total

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