BACKGROUND: For the management of endoscopically irretrievable polyps, several minimally invasive procedures are currently available as alternatives to conventional laparotomy. However, the high rate of malignant transformation despite initially benign histology continues to be a problem. METHODS: Within the framework of a prospective multicenter observational study, all patients with adenomatous polyps unsuitable for endoscopic removal and with benign histology were investigated. In addition to an analysis of the perioperative course and the definitive histology, the overall and disease-free survival rates of patients with malignant transformation of colorectal adenomas were also calculated. RESULTS: A total of 525 patients (median age 65.3 years; median body mass index 25.6 kg/m(2)) underwent a laparoscopic resection. Conversion to laparotomy became necessary in 17 (3.2%) cases. The perioperative morbidity rate was 20.8%, and malignant transformation occurred in a total of 18.1% of the adenomatous polyps. The median number of lymph nodes removed was 12, and lymph node metastases were seen in a total of 14.8% of the patients (T1--4.8%, T2--19.4%, T3--25%, T4--100%). Estimated 5-year overall and disease-free survival rates were 92.4% and 80.6%, respectively. CONCLUSIONS: For the management of endoscopically unresectable polyps, laparoscopic resection is currently the technique of choice. In addition to the benefits of minimally invasive surgery, in the hands of an experienced surgeon it achieves results comparable with those of open surgery. In view of the high rate of malignant transformation and the absence of unequivocal factors predictive of already present malignant transformation, an oncologically radical operation is essential. In the elderly patient presenting with comorbidities limited resection aiming to minimize surgical trauma in potentially benign disease may be considered. In such a case, however, frozen-section histology is obligatory.
BACKGROUND: For the management of endoscopically irretrievable polyps, several minimally invasive procedures are currently available as alternatives to conventional laparotomy. However, the high rate of malignant transformation despite initially benign histology continues to be a problem. METHODS: Within the framework of a prospective multicenter observational study, all patients with adenomatous polyps unsuitable for endoscopic removal and with benign histology were investigated. In addition to an analysis of the perioperative course and the definitive histology, the overall and disease-free survival rates of patients with malignant transformation of colorectal adenomas were also calculated. RESULTS: A total of 525 patients (median age 65.3 years; median body mass index 25.6 kg/m(2)) underwent a laparoscopic resection. Conversion to laparotomy became necessary in 17 (3.2%) cases. The perioperative morbidity rate was 20.8%, and malignant transformation occurred in a total of 18.1% of the adenomatous polyps. The median number of lymph nodes removed was 12, and lymph node metastases were seen in a total of 14.8% of the patients (T1--4.8%, T2--19.4%, T3--25%, T4--100%). Estimated 5-year overall and disease-free survival rates were 92.4% and 80.6%, respectively. CONCLUSIONS: For the management of endoscopically unresectable polyps, laparoscopic resection is currently the technique of choice. In addition to the benefits of minimally invasive surgery, in the hands of an experienced surgeon it achieves results comparable with those of open surgery. In view of the high rate of malignant transformation and the absence of unequivocal factors predictive of already present malignant transformation, an oncologically radical operation is essential. In the elderly patient presenting with comorbidities limited resection aiming to minimize surgical trauma in potentially benign disease may be considered. In such a case, however, frozen-section histology is obligatory.
Authors: A D'Annibale; E Morpurgo; V Fiscon; B Termini; A Serventi; G Sovernigo; C Orsini Journal: Tech Coloproctol Date: 2006-11-27 Impact factor: 3.781
Authors: Antonio M Lacy; Juan C García-Valdecasas; Salvadora Delgado; Antoni Castells; Pilar Taurá; Josep M Piqué; Josep Visa Journal: Lancet Date: 2002-06-29 Impact factor: 79.321
Authors: Heidi Nelson; Daniel J Sargent; H Sam Wieand; James Fleshman; Mehran Anvari; Steven J Stryker; Robert W Beart; Michael Hellinger; Richard Flanagan; Walter Peters; David Ota Journal: N Engl J Med Date: 2004-05-13 Impact factor: 91.245
Authors: Joon Ho Jang; Emre Balik; Daniel Kirchoff; Wouter Tromp; Anjali Kumar; Michael Grieco; Daniel L Feingold; Vesna Cekic; Linda Njoh; Richard L Whelan Journal: J Gastrointest Surg Date: 2011-11-05 Impact factor: 3.452
Authors: Matthew D Rutter; Amit Chattree; Jamie A Barbour; Siwan Thomas-Gibson; Pradeep Bhandari; Brian P Saunders; Andrew M Veitch; John Anderson; Bjorn J Rembacken; Maurice B Loughrey; Rupert Pullan; William V Garrett; Gethin Lewis; Sunil Dolwani Journal: Gut Date: 2015-06-23 Impact factor: 23.059
Authors: Sophie Sf Hon; Simon Sm Ng; Tiffany Cl Wong; Philip Wy Chiu; Tony Wc Mak; W W Leung; Janet Fy Lee Journal: World J Gastrointest Endosc Date: 2015-11-25
Authors: Fernando A Angarita; Adina E Feinberg; Stanley M Feinberg; Robert H Riddell; J Andrea McCart Journal: Int J Colorectal Dis Date: 2017-12-28 Impact factor: 2.571