Literature DB >> 21278230

Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Jarrod R Fortwendel1, Praveen R Juvvadi, Luise E Rogg, William J Steinbach.   

Abstract

Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.

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Year:  2011        PMID： 21278230      PMCID： PMC3127644          DOI： 10.1128/EC.00315-10

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  19 in total

1.  A Ras protein from a phytopathogenic fungus causes defects in hyphal growth polarity, and induces tumors in mice.

Authors:  G M Truesdell; C Jones; T Holt; G Henderson; M B Dickman
Journal:  Mol Gen Genet       Date:  1999-08

2.  RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.

Authors:  J A Alspaugh; L M Cavallo; J R Perfect; J Heitman
Journal:  Mol Microbiol       Date:  2000-04       Impact factor: 3.501

3.  Role of a ras homolog in the life cycle of Schizosaccharomyces pombe.

Authors:  Y Fukui; T Kozasa; Y Kaziro; T Takeda; M Yamamoto
Journal:  Cell       Date:  1986-01-31       Impact factor: 41.582

4.  Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6.

Authors:  Haymanti Bhanot; Ashley M Young; Jean H Overmeyer; William A Maltese
Journal:  Mol Cancer Res       Date:  2010-08-16       Impact factor: 5.852

5.  Ras signaling is required for serum-induced hyphal differentiation in Candida albicans.

Authors:  Q Feng; E Summers; B Guo; G Fink
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

6.  Developmental decisions in Aspergillus nidulans are modulated by Ras activity.

Authors:  T Som; V S Kolaparthi
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

7.  Functional analysis of Ras in Colletotrichum trifolii.

Authors:  Young-sil Ha; Stephen D Memmott; Martin B Dickman
Journal:  FEMS Microbiol Lett       Date:  2003-09-26       Impact factor: 2.742

8.  Genetic analysis of yeast RAS1 and RAS2 genes.

Authors:  T Kataoka; S Powers; C McGill; O Fasano; J Strathern; J Broach; M Wigler
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

9.  Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development.

Authors:  Jarrod R Fortwendel; John C Panepinto; Amy E Seitz; David S Askew; Judith C Rhodes
Journal:  Fungal Genet Biol       Date:  2004-02       Impact factor: 3.495

10.  Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signalling pathways.

Authors:  Changbin Chen; Martin B Dickman
Journal:  Mol Microbiol       Date:  2004-03       Impact factor: 3.501
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  12 in total

1.  Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi.

Authors:  Jarrod R Fortwendel
Journal:  Fungal Genom Biol       Date:  2012

Review 2.  Control of Ras-mediated signaling in Aspergillus fumigatus.

Authors:  Tiffany S Norton; Jarrod R Fortwendel
Journal:  Mycopathologia       Date:  2014-06-22       Impact factor: 2.574

Review 3.  Fungal morphogenesis.

Authors:  Xiaorong Lin; J Andrew Alspaugh; Haoping Liu; Steven Harris
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-03       Impact factor: 6.915

Review 4.  Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments.

Authors:  William A Maltese; Jean H Overmeyer
Journal:  Am J Pathol       Date:  2014-04-13       Impact factor: 4.307

5.  Orchestration of Morphogenesis in Filamentous Fungi: Conserved Roles for Ras Signaling Networks.

Authors:  Jarrod R Fortwendel
Journal:  Fungal Biol Rev       Date:  2015-06-01       Impact factor: 4.706

6.  Disparate proteome responses of pathogenic and nonpathogenic aspergilli to human serum measured by activity-based protein profiling (ABPP).

Authors:  Susan D Wiedner; Charles Ansong; Bobbie-Jo Webb-Robertson; LeeAnna M Pederson; Suereta Fortuin; Beth A Hofstad; Anil K Shukla; Ellen A Panisko; Richard D Smith; Aaron T Wright
Journal:  Mol Cell Proteomics       Date:  2013-04-18       Impact factor: 5.911

7.  Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.

Authors:  Jarrod R Fortwendel; Praveen R Juvvadi; Luise E Rogg; Yohannes G Asfaw; Kimberlie A Burns; Scott H Randell; William J Steinbach
Journal:  Eukaryot Cell       Date:  2012-05-04

8.  A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus.

Authors:  Qusai Al Abdallah; Tiffany S Norton; Amy M Hill; Lawrence L LeClaire; Jarrod R Fortwendel
Journal:  mSphere       Date:  2016-11-30       Impact factor: 4.389

9.  The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.

Authors:  Tiffany S Norton; Qusai Al Abdallah; Amy M Hill; Rachel V Lovingood; Jarrod R Fortwendel
Journal:  Virulence       Date:  2017-05-10       Impact factor: 5.882

Review 10.  Non-apoptotic cell death associated with perturbations of macropinocytosis.

Authors:  William A Maltese; Jean H Overmeyer
Journal:  Front Physiol       Date:  2015-02-16       Impact factor: 4.566
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