Literature DB >> 18595010

Glioma formation, cancer stem cells, and akt signaling.

Dolores Hambardzumyan1, Massimo Squatrito, Eletha Carbajal, Eric C Holland.   

Abstract

Several recent reports have provided evidence that cancer is initiated by a rare fraction of cells called "cancer stem cells" which are multipotent, self-renewing subset of the tumor. However, several issues regarding the biology and techniques of isolating these cells from solid tumors remain to be clarified. In addition, experimental data supports two possibilities for glioma cell of origin. First, that stem cells or early progenitors are transformed and show variable differentiation of their progeny during tumor development. Second, that more differentiated glia are transformed by genetic events that lead to a loss of differentiation maintenance. In human gliomas, these two theories are not mutually exclusive. In this review we will summarize both theories, and highlight outstanding issues that remain to be resolved.

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Year:  2008        PMID： 18595010     DOI： 10.1007/s12015-008-9021-5

Source DB:  PubMed          Journal:  Stem Cell Rev        ISSN： 1550-8943            Impact factor:   5.739


  75 in total

1.  Radiation resistance and stem-like cells in brain tumors.

Authors:  Dolores Hambardzumyan; Massimo Squatrito; Massimo Squartro; Eric C Holland
Journal:  Cancer Cell       Date:  2006-12       Impact factor: 31.743

2.  p53 suppresses the self-renewal of adult neural stem cells.

Authors:  Konstantinos Meletis; Valtteri Wirta; Sanna-Maria Hede; Monica Nistér; Joakim Lundeberg; Jonas Frisén
Journal:  Development       Date:  2006-01       Impact factor: 6.868

3.  Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice.

Authors:  Andrew B Lassman; Chengkai Dai; Gregory N Fuller; Andrew J Vickers; Eric C Holland
Journal:  Neuron Glia Biol       Date:  2004-05

Review 4.  Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment.

Authors:  Elena I Fomchenko; Eric C Holland
Journal:  Neurosurg Clin N Am       Date:  2007-01       Impact factor: 2.509

5.  Development of glial cells in the cerebral wall of ferrets: direct tracing of their transformation from radial glia into astrocytes.

Authors:  T Voigt
Journal:  J Comp Neurol       Date:  1989-11-01       Impact factor: 3.215

6.  Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro.

Authors:  Tatyana N Ignatova; Valery G Kukekov; Eric D Laywell; Oleg N Suslov; Frank D Vrionis; Dennis A Steindler
Journal:  Glia       Date:  2002-09       Impact factor: 7.452

7.  CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.

Authors:  Jian Wang; Per Ø Sakariassen; Oleg Tsinkalovsky; Heike Immervoll; Stig Ove Bøe; Agnete Svendsen; Lars Prestegarden; Gro Røsland; Frits Thorsen; Linda Stuhr; Anders Molven; Rolf Bjerkvig; Per Ø Enger
Journal:  Int J Cancer       Date:  2008-02-15       Impact factor: 7.396

8.  Identification of pancreatic cancer stem cells.

Authors:  Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal:  Cancer Res       Date:  2007-02-01       Impact factor: 12.701

9.  Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

Authors:  Lene Uhrbom; Chengkai Dai; Joseph C Celestino; Marc K Rosenblum; Gregory N Fuller; Eric C Holland
Journal:  Cancer Res       Date:  2002-10-01       Impact factor: 12.701

Review 10.  Prostate cancer stem cells: a target for new therapies.

Authors:  N J Maitland; S D Bryce; M J Stower; A T Collins
Journal:  Ernst Schering Found Symp Proc       Date:  2006
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  52 in total

Review 1.  Cancer stem cells: a novel paradigm for cancer prevention and treatment.

Authors:  Dharmalingam Subramaniam; Satish Ramalingam; Courtney W Houchen; Shrikant Anant
Journal:  Mini Rev Med Chem       Date:  2010-05       Impact factor: 3.862

2.  Brain cancer stem cells display preferential sensitivity to Akt inhibition.

Authors:  Christine E Eyler; Wen-Chi Foo; Katherine M LaFiura; Roger E McLendon; Anita B Hjelmeland; Jeremy N Rich
Journal:  Stem Cells       Date:  2008-09-18       Impact factor: 6.277

3.  Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.

Authors:  Huailei Liu; Dayong Han; Yaohua Liu; Xu Hou; Jianing Wu; Huadong Li; Jie Yang; Chen Shen; Guang Yang; Changyu Fu; Xianfeng Li; Hui Che; Jing Ai; Shiguang Zhao
Journal:  J Neurooncol       Date:  2013-02-08       Impact factor: 4.130

4.  Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells.

Authors:  Yuanyan Wei; Yizhou Jiang; Fei Zou; Yingchao Liu; Shanshan Wang; Nuo Xu; Wenlong Xu; Chunhong Cui; Yang Xing; Ying Liu; Benjin Cao; Chanjuan Liu; Guoqiang Wu; Hong Ao; Xiaobiao Zhang; Jianhai Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-08       Impact factor: 11.205

5.  Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

Authors:  Roberto Würth; Alessandra Pattarozzi; Monica Gatti; Adirano Bajetto; Alessandro Corsaro; Alessia Parodi; Rodolfo Sirito; Michela Massollo; Cecilia Marini; Gianluigi Zona; Daniela Fenoglio; Gianmario Sambuceti; Gilberto Filaci; Antonio Daga; Federica Barbieri; Tullio Florio
Journal:  Cell Cycle       Date:  2012-12-19       Impact factor: 4.534

Review 6.  The bright and the dark sides of DNA repair in stem cells.

Authors:  Guido Frosina
Journal:  J Biomed Biotechnol       Date:  2010-04-08

7.  Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

Authors:  Venkata Ramesh Dasari; Kiranpreet Kaur; Kiran Kumar Velpula; Meena Gujrati; Daniel Fassett; Jeffrey D Klopfenstein; Dzung H Dinh; Jasti S Rao
Journal:  PLoS One       Date:  2010-04-26       Impact factor: 3.240

8.  Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes.

Authors:  Alessandro Ruggiero; Carlos H Villa; Jason P Holland; Shanna R Sprinkle; Chad May; Jason S Lewis; David A Scheinberg; Michael R McDevitt
Journal:  Int J Nanomedicine       Date:  2010-10-05

9.  Breast cancer biology: the multifaceted roles of mesenchymal stem cells.

Authors:  Shyam A Patel; Andrew C Heinrich; Bobby Y Reddy; Balaji Srinivas; Nicole Heidaran; Pranela Rameshwar
Journal:  J Oncol       Date:  2008-12-21       Impact factor: 4.375

10.  The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas.

Authors:  Eiron Cudaback; William Marrs; Thomas Moeller; Nephi Stella
Journal:  PLoS One       Date:  2010-01-14       Impact factor: 3.240
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