| Literature DB >> 18587397 |
Michal Pravenec1, Paul C Churchill, Monique C Churchill, Ondrej Viklicky, Ludmila Kazdova, Timothy J Aitman, Enrico Petretto, Norbert Hubner, Caroline A Wallace, Heike Zimdahl, Vaclav Zidek, Vladimir Landa, Joseph Dunbar, Anil Bidani, Karen Griffin, Nathan Qi, Martina Maxova, Vladimir Kren, Petr Mlejnek, Jiaming Wang, Theodore W Kurtz.
Abstract
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18587397 DOI： 10.1038/ng.164
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330