Literature DB >> 19185504

Cellular fatty acid uptake: a pathway under construction.

Xiong Su1, Nada A Abumrad.   

Abstract

Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues. This review highlights the contribution of CD36 to pathophysiology in rodents and humans. Novel concepts regarding regulation of CD36-facilitated uptake are discussed (i.e. the role of membrane rafts and caveolae, CD36 recycling between intracellular depots and the membrane, and chemical modifications of the protein that impact its turnover and recruitment). Importantly, CD36 membrane levels and turnover are abnormal in diabetes, resulting in dysfunctional FA utilization. In addition, variants in the CD36 gene were shown recently to influence susceptibility for the metabolic syndrome, which greatly increases the risk of diabetes and heart disease.

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Year:  2009        PMID： 19185504      PMCID： PMC2845711          DOI： 10.1016/j.tem.2008.11.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  74 in total

1.  A new role for caveolae as metabolic platforms.

Authors:  Unn Ortegren; Nabila Aboulaich; Anita Ost; Peter Strålfors
Journal:  Trends Endocrinol Metab       Date:  2007-11       Impact factor: 12.015

2.  Gene expression in human NAFLD.

Authors:  Dario Greco; Anna Kotronen; Jukka Westerbacka; Oscar Puig; Perttu Arkkila; Tuula Kiviluoto; Saara Laitinen; Maria Kolak; Rachel M Fisher; Anders Hamsten; Petri Auvinen; Hannele Yki-Järvinen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-04-03       Impact factor: 4.052

3.  CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.

Authors:  N Tao; S J Wagner; D M Lublin
Journal:  J Biol Chem       Date:  1996-09-13       Impact factor: 5.157

4.  Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.

Authors:  Babak Razani; Terry P Combs; Xiao Bo Wang; Philippe G Frank; David S Park; Robert G Russell; Maomi Li; Baiyu Tang; Linda A Jelicks; Philipp E Scherer; Michael P Lisanti
Journal:  J Biol Chem       Date:  2001-12-05       Impact factor: 5.157

5.  Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids.

Authors:  Hiroshi Irie; Irvin B Krukenkamp; Joep F F Brinkmann; Glenn R Gaudette; Adam E Saltman; William Jou; Jan F C Glatz; Nada A Abumrad; Azeddine Ibrahimi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-13       Impact factor: 11.205

Review 6.  Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription.

Authors:  Friedhelm Schroeder; Anca D Petrescu; Huan Huang; Barbara P Atshaves; Avery L McIntosh; Gregory G Martin; Heather A Hostetler; Aude Vespa; Danilo Landrock; Kerstin K Landrock; H Ross Payne; Ann B Kier
Journal:  Lipids       Date:  2007-09-19       Impact factor: 1.880

7.  CD36 deficiency rescues lipotoxic cardiomyopathy.

Authors:  John Yang; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Attila Kovacs; Maria Febbraio; Brian N Finck; Daniel P Kelly
Journal:  Circ Res       Date:  2007-03-15       Impact factor: 17.367

Review 8.  Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins.

Authors:  Robert Ehehalt; Joachim Füllekrug; Jürgen Pohl; Axel Ring; Thomas Herrmann; Wolfgang Stremmel
Journal:  Mol Cell Biochem       Date:  2006-02-14       Impact factor: 3.396

9.  Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.

Authors:  Jie Zhou; Maria Febbraio; Taira Wada; Yonggong Zhai; Ramalinga Kuruba; Jinhan He; Jung Hoon Lee; Shaheen Khadem; Songrong Ren; Song Li; Roy L Silverstein; Wen Xie
Journal:  Gastroenterology       Date:  2007-11-28       Impact factor: 22.682

10.  CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.

Authors:  Fatiha Nassir; Brody Wilson; Xianlin Han; Richard W Gross; Nada A Abumrad
Journal:  J Biol Chem       Date:  2007-05-15       Impact factor: 5.157
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  125 in total

1.  Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans.

Authors:  Kathleen L Keller; Lisa C H Liang; Johannah Sakimura; Daniel May; Christopher van Belle; Cameron Breen; Elissa Driggin; Beverly J Tepper; Patricia C Lanzano; Liyong Deng; Wendy K Chung
Journal:  Obesity (Silver Spring)       Date:  2012-01-12       Impact factor: 5.002

2.  Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia.

Authors:  X Rong; Y Li; K Ebihara; M Zhao; T Kusakabe; T Tomita; M Murray; K Nakao
Journal:  Br J Pharmacol       Date:  2010-08       Impact factor: 8.739

Review 3.  Understanding the impact of taste changes in oncology care.

Authors:  Joel B Epstein; Gregory Smutzer; Richard L Doty
Journal:  Support Care Cancer       Date:  2016-01-28       Impact factor: 3.603

Review 4.  Genome-based nutrition: an intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis.

Authors:  Sonia Roman; Claudia Ojeda-Granados; Omar Ramos-Lopez; Arturo Panduro
Journal:  World J Gastroenterol       Date:  2015-03-28       Impact factor: 5.742

5.  Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.

Authors:  Dmitri Samovski; Xiong Su; Yingcheng Xu; Nada A Abumrad; Philip D Stahl
Journal:  J Lipid Res       Date:  2012-02-06       Impact factor: 5.922

6.  CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis.

Authors:  Robin D Clugston; Jason J Yuen; Yunying Hu; Nada A Abumrad; Paul D Berk; Ira J Goldberg; William S Blaner; Li-Shin Huang
Journal:  J Lipid Res       Date:  2013-11-26       Impact factor: 5.922

7.  Measurement of long-chain fatty acid uptake into adipocytes.

Authors:  Elena Dubikovskaya; Rostislav Chudnovskiy; Grigory Karateev; Hyo Min Park; Andreas Stahl
Journal:  Methods Enzymol       Date:  2014       Impact factor: 1.600

8.  CD36 genetic variation, fat intake and liver fibrosis in chronic hepatitis C virus infection.

Authors:  Omar Ramos-Lopez; Sonia Roman; Erika Martinez-Lopez; Nora A Fierro; Karina Gonzalez-Aldaco; Alexis Jose-Abrego; Arturo Panduro
Journal:  World J Hepatol       Date:  2016-09-08

9.  Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner.

Authors:  Eric K Long; Kristina Hellberg; Rocio Foncea; Ann V Hertzel; Jill Suttles; David A Bernlohr
Journal:  Biochim Biophys Acta       Date:  2013-04-12

10.  A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon coloration.

Authors:  Takashi Sakudoh; Tetsuya Iizuka; Junko Narukawa; Hideki Sezutsu; Isao Kobayashi; Seigo Kuwazaki; Yutaka Banno; Akitoshi Kitamura; Hiromu Sugiyama; Naoko Takada; Hirofumi Fujimoto; Keiko Kadono-Okuda; Kazuei Mita; Toshiki Tamura; Kimiko Yamamoto; Kozo Tsuchida
Journal:  J Biol Chem       Date:  2010-01-06       Impact factor: 5.157
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