Literature DB >> 18584115

Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

Joachim Denner1.   

Abstract

PERVs are integrated in the genome of all pigs. Some of them infect human cells and represent therefore a potential risk for xenotransplantation using pig cells or organs. Three replication-competent subtypes have been described, PERV-A, PERV-B and PERV-C. Whereas PERV-A and PERV-B are polytropic viruses and infect, among others, human cells, PERV-C is an ecotropic virus, infecting only pig cells. Recombinant PERV-A/C are able to infect human cells, they are characterised by high-titre replication and their proviruses have been found de novo integrated in the genome of somatic pig cells, but not in the germ line. This review compares recombinant PERVs with other recombinant retroviruses in order to evaluate their potential pathogenicity.

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Mesh：

Year:  2008        PMID： 18584115     DOI： 10.1007/s00705-008-0141-7

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  33 in total

1.  Retroviral restriction factors and infectious risk in xenotransplantation.

Authors:  Y Meije; R R Tönjes; J A Fishman
Journal:  Am J Transplant       Date:  2010-07       Impact factor: 8.086

2.  Fluidized-bed bioartificial liver assist devices (BLADs) based on microencapsulated primary porcine hepatocytes have risk of porcine endogenous retroviruses transmission.

Authors:  Qian Yang; Fei Liu; Xiao Ping Pan; Guoliang Lv; Anye Zhang; Chen Bo Yu; Lanjuan Li
Journal:  Hepatol Int       Date:  2010-08-15       Impact factor: 6.047

3.  Long-term safety from transmission of porcine endogenous retrovirus after pig-to-non-human primate corneal transplantation.

Authors:  Hyuk Jin Choi; Jiyeon Kim; Jae Young Kim; Hyun Ju Lee; Won Ryang Wee; Mee Kum Kim; Eung Soo Hwang
Journal:  Xenotransplantation       Date:  2017-05-14       Impact factor: 3.907

Review 4.  Optimal pig donor selection in islet xenotransplantation: current status and future perspectives.

Authors:  Hai-tao Zhu; Liang Yu; Yi Lyu; Bo Wang
Journal:  J Zhejiang Univ Sci B       Date:  2014-08       Impact factor: 3.066

5.  Screening pigs for xenotransplantation: expression of porcine endogenous retroviruses in transgenic pig skin.

Authors:  Magdalena Kimsa-Dudek; Barbara Strzalka-Mrozik; Malgorzata W Kimsa; Irena Blecharz; Joanna Gola; Bartlomiej Skowronek; Adrian Janiszewski; Daniel Lipinski; Joanna Zeyland; Marlena Szalata; Ryszard Slomski; Urszula Mazurek
Journal:  Transgenic Res       Date:  2015-03-27       Impact factor: 2.788

Review 6.  Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.

Authors:  Joachim Denner; Ralf R Tönjes
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

7.  Regulation of porcine endogenous retrovirus release by porcine and human tetherins.

Authors:  Giada Mattiuzzo; Sabrina Ivol; Yasuhiro Takeuchi
Journal:  J Virol       Date:  2009-12-16       Impact factor: 5.103

8.  Identification and promoter analysis of PERV LTR subtypes in NIH-miniature pig.

Authors:  Yi-Deun Jung; Hong-Seok Ha; Sang-Je Park; Keon-Bong Oh; Gi-Sun Im; Tae-Hun Kim; Hwan-Hoo Seong; Heui-Soo Kim
Journal:  Mol Cells       Date:  2013-02-21       Impact factor: 5.034

9.  Detection of a gammaretrovirus, XMRV, in the human population: open questions and implications for xenotransplantation.

Authors:  Joachim Denner
Journal:  Retrovirology       Date:  2010-03-10       Impact factor: 4.602

Review 10.  Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?

Authors:  Burcin Ekser; Bruno Gridelli; A Joseph Tector; David K C Cooper
Journal:  Transplantation       Date:  2009-11-15       Impact factor: 4.939
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