Literature DB >> 18568776

Expression of multidrug resistance genes in normal and cancer stem cells.

A Shervington1, C Lu.   

Abstract

CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. Glioma tissues contained higher ratio of CD133+ cells compared to normal tissues ( approximately 10 fold increase). The chemosensitivity assay showed that GOS-3 and NHA CD133+ possess greater resistance towards drugs compared to CD133- fractions. This study revealed for the first time that: a) serum deprivation enriched CD133 expression and demonstrated a direct co-expression between CD133 and drug resistant in GOS-3 cells and b) higher expression of CD133 and drug resistance were found in glioblastoma tissues in comparison to normal brain tissues.

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Year:  2008        PMID： 18568776     DOI： 10.1080/07357900801904140

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  42 in total

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Review 4.  New promising drug targets in cancer- and metastasis-initiating cells.

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Journal:  Drug Discov Today       Date:  2010-03-23       Impact factor: 7.851

Review 5.  Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain.

Authors:  Sagar Agarwal; Ramola Sane; Rajneet Oberoi; John R Ohlfest; William F Elmquist
Journal:  Expert Rev Mol Med       Date:  2011-05-13       Impact factor: 5.600

6.  Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance.

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Review 7.  Cancer stem cells and drug resistance: the potential of nanomedicine.

Authors:  Serguei Vinogradov; Xin Wei
Journal:  Nanomedicine (Lond)       Date:  2012-04       Impact factor: 5.307

Review 8.  Therapeutic targeting of gastrointestinal cancer stem cells.

Authors:  Jonathan Stem; John C Flickinger; Dante Merlino; Ellen M Caparosa; Adam E Snook; Scott A Waldman
Journal:  Regen Med       Date:  2019-04-26       Impact factor: 3.806

9.  Flow cytometry analysis of neural differentiation markers expression in human glioblastomas may predict their response to chemotherapy.

Authors:  Vladimir Balik; Peter Mirossay; Peter Bohus; Igor Sulla; Ladislav Mirossay; Marek Sarissky
Journal:  Cell Mol Neurobiol       Date:  2009-03-14       Impact factor: 5.046

10.  Breast cancer biology: the multifaceted roles of mesenchymal stem cells.

Authors:  Shyam A Patel; Andrew C Heinrich; Bobby Y Reddy; Balaji Srinivas; Nicole Heidaran; Pranela Rameshwar
Journal:  J Oncol       Date:  2008-12-21       Impact factor: 4.375
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