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Literature DB >> 31025613

Therapeutic targeting of gastrointestinal cancer stem cells.

Jonathan Stem¹, John C Flickinger², Dante Merlino², Ellen M Caparosa^1,2, Adam E Snook², Scott A Waldman².

Abstract

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.

Entities: Disease

Keywords: cancer stem cells; chemoresistance; gastrointestinal cancer; immunotherapy; radioresistance; targeted therapies

Mesh：

Year: 2019 PMID： 31025613 PMCID： PMC6886570 DOI： 10.2217/rme-2018-0146

Source DB: PubMed Journal: Regen Med ISSN： 1746-0751 Impact factor: 3.806

93 in total

1. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule.

Authors: Sarah Shigdar; Jia Lin; Yan Yu; Mile Pastuovic; Ming Wei; Wei Duan
Journal: Cancer Sci Date: 2011-03-14 Impact factor: 6.716

Review 2. Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.

Authors: Chung-Pu Wu; Anna Maria Calcagno; Suresh V Ambudkar
Journal: Curr Mol Pharmacol Date: 2008-06 Impact factor: 3.339

3. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors: Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal: Nature Date: 2006-10-18 Impact factor: 49.962

4. Differentiation and reversal of malignant changes in colon cancer through PPARgamma.

Authors: P Sarraf; E Mueller; D Jones; F J King; D J DeAngelo; J B Partridge; S A Holden; L B Chen; S Singer; C Fletcher; B M Spiegelman
Journal: Nat Med Date: 1998-09 Impact factor: 53.440

Review 5. Cancer stem cells: a potential target for cancer therapy.

Authors: Hong Qiu; Xiaoguang Fang; Qi Luo; Gaoliang Ouyang
Journal: Cell Mol Life Sci Date: 2015-05-13 Impact factor: 9.261

6. ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from colon cancer.

Authors: Zheng-Yuan Xie; Ke Lv; Ying Xiong; Wu-Hua Guo
Journal: Oncol Res Treat Date: 2014-10-17 Impact factor: 2.825

7. Retinoid receptors in gastric cancer: expression and influence on prognosis.

Authors: Kong-Wang Hu; Fei-Hu Chen; Jin-Fang Ge; Li-Yu Cao; Hao Li
Journal: Asian Pac J Cancer Prev Date: 2012

8. Phenotypic characterization of human colorectal cancer stem cells.

Authors: Piero Dalerba; Scott J Dylla; In-Kyung Park; Rui Liu; Xinhao Wang; Robert W Cho; Timothy Hoey; Austin Gurney; Emina H Huang; Diane M Simeone; Andrew A Shelton; Giorgio Parmiani; Chiara Castelli; Michael F Clarke
Journal: Proc Natl Acad Sci U S A Date: 2007-06-04 Impact factor: 11.205

9. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8⁺ T cells.

Authors: Hung-Chang Chen; Noémie Joalland; John S Bridgeman; Fouad S Alchami; Ulrich Jarry; Mohd Wajid A Khan; Luke Piggott; Yasmin Shanneik; Jianqiang Li; Marco J Herold; Thomas Herrmann; David A Price; Awen M Gallimore; Richard W Clarkson; Emmanuel Scotet; Bernhard Moser; Matthias Eberl
Journal: Immunol Cell Biol Date: 2017-03-30 Impact factor: 5.126