Literature DB >> 20338259

New promising drug targets in cancer- and metastasis-initiating cells.

Murielle Mimeault1, Surinder K Batra.   

Abstract

The unique properties of cancer- and metastasis-initiating cells endowed with a high self-renewal and aberrant differentiation potential (including their elevated expression levels of anti-apoptotic factors, multidrug transporters, and DNA repair and detoxifying enzymes) might be associated with their resistance to current clinical cancer therapies and disease recurrence. The eradication of cancer- and metastasis-initiating cells by molecular targeting of distinct deregulated signaling elements that might contribute to their sustained growth, survival, and treatment resistance, therefore, is of immense therapeutic interest. These novel targeted approaches should improve the efficacy of current therapeutic treatments against highly aggressive, metastatic, recurrent, and lethal cancers. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20338259      PMCID： PMC2906246          DOI： 10.1016/j.drudis.2010.03.009

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  166 in total

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  21 in total

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Review 2.  Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies.

Authors:  Murielle Mimeault; Surinder K Batra
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Review 3.  Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.

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Journal:  Brain Pathol       Date:  2011-07-07       Impact factor: 6.508

Review 4.  Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor- and metastasis-initiating cells and their progenies.

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5.  New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients.

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Review 6.  Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.

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Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

7.  Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells.

Authors:  K S R Sastry; M A Al-Muftah; Pu Li; M K Al-Kowari; E Wang; A Ismail Chouchane; D Kizhakayil; G Kulik; F M Marincola; A Haoudi; L Chouchane
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Review 8.  Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers.

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9.  Aberrant Expression of Cancer Stem Cells Marker Prominin-1 in Low-Grade Tubulolobular Breast Carcinoma: A Correlative Study between qRT-PCR, Flow-Cytometric and Immunohistochemistry Analysis [corrected].

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10.  Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells.

Authors:  Murielle Mimeault; Surinder K Batra
Journal:  J Cell Mol Med       Date:  2013-01-10       Impact factor: 5.310
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