Literature DB >> 1856854

Binding of the anticodon domain of tRNA(fMet) to Escherichia coli methionyl-tRNA synthetase.

T Meinnel1, Y Mechulam, S Blanquet, G Fayat.   

Abstract

A stem and loop RNA domain carrying the methionine anticodon (CAU) was designed from the tRNA(fMet) sequence and produced in vitro. This domain makes a complex with methionyl-tRNA synthetase (Kd = 38(+/- 5) microM; 25 degrees C, pH 7.6, 7 mM-MgCl2). The formation of this complex is dependent on the presence of the cognate CAU anticodon sequence. Recognition of this RNA domain is abolished by a methionyl-tRNA synthetase mutation known to alter the binding of tRNA(Met).

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Year:  1991        PMID： 1856854     DOI： 10.1016/0022-2836(91)90003-o

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  8 in total

1.  The anticodon triplet is not sufficient to confer methionine acceptance to a transfer RNA.

Authors:  B Senger; L Despons; P Walter; F Fasiolo
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

2.  Anticodon-independent aminoacylation of an RNA minihelix with valine.

Authors:  M Frugier; C Florentz; R Giegé
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

3.  A study of communication pathways in methionyl- tRNA synthetase by molecular dynamics simulations and structure network analysis.

Authors:  Amit Ghosh; Saraswathi Vishveshwara
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-26       Impact factor: 11.205

4.  L-arginine recognition by yeast arginyl-tRNA synthetase.

Authors:  J Cavarelli; B Delagoutte; G Eriani; J Gangloff; D Moras
Journal:  EMBO J       Date:  1998-09-15       Impact factor: 11.598

5.  Involvement of the size and sequence of the anticodon loop in tRNA recognition by mammalian and E. coli methionyl-tRNA synthetases.

Authors:  T Meinnel; Y Mechulam; G Fayat; S Blanquet
Journal:  Nucleic Acids Res       Date:  1992-09-25       Impact factor: 16.971

6.  Molecular mimicry in translational control of E. coli threonyl-tRNA synthetase gene. Competitive inhibition in tRNA aminoacylation and operator-repressor recognition switch using tRNA identity rules.

Authors:  P Romby; C Brunel; J Caillet; M Springer; M Grunberg-Manago; E Westhof; C Ehresmann; B Ehresmann
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

Review 7.  Experimental studies on the origin of the genetic code and the process of protein synthesis: a review update.

Authors:  J C Lacey; N S Wickramasinghe; G W Cook
Journal:  Orig Life Evol Biosph       Date:  1992       Impact factor: 1.950

8.  Efficient aminoacylation of resected RNA helices by class II aspartyl-tRNA synthetase dependent on a single nucleotide.

Authors:  M Frugier; C Florentz; R Giegé
Journal:  EMBO J       Date:  1994-05-01       Impact factor: 11.598
  8 in total

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