Literature DB >> 18550601

Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition.

Min He1, Jiyang Cai, Young-Mi Go, Jennifer M Johnson, W David Martin, Jason M Hansen, Dean P Jones.   

Abstract

Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.

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Year:  2008        PMID： 18550601      PMCID： PMC2734306          DOI： 10.1093/toxsci/kfn116

Source DB:  PubMed          Journal:  Toxicol Sci        ISSN： 1096-0929            Impact factor:   4.849


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