Literature DB >> 20368370

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria.

Dean P Jones1, John J Lemasters, Derick Han, Urs A Boelsterli, Neil Kaplowitz.   

Abstract

Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.

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Year:  2010        PMID： 20368370      PMCID： PMC2895369          DOI： 10.1124/mi.10.2.7

Source DB:  PubMed          Journal:  Mol Interv        ISSN： 1534-0384


  121 in total

1.  The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.

Authors:  Xian-Ping Dong; Xiping Cheng; Eric Mills; Markus Delling; Fudi Wang; Tino Kurz; Haoxing Xu
Journal:  Nature       Date:  2008-09-14       Impact factor: 49.962

2.  The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.

Authors:  Anna W C Leung; Pinadda Varanyuwatana; Andrew P Halestrap
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157

Review 3.  Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies.

Authors:  Gilles Labbe; Dominique Pessayre; Bernard Fromenty
Journal:  Fundam Clin Pharmacol       Date:  2008-08       Impact factor: 2.748

Review 4.  Radical-free biology of oxidative stress.

Authors:  Dean P Jones
Journal:  Am J Physiol Cell Physiol       Date:  2008-08-06       Impact factor: 4.249

Review 5.  Cellular and molecular mechanisms of liver injury.

Authors:  Harmeet Malhi; Gregory J Gores
Journal:  Gastroenterology       Date:  2008-05       Impact factor: 22.682

6.  Increased mitochondrial thioredoxin 2 potentiates N-ethylmaleimide-induced cytotoxicity.

Authors:  Yan Chen; Young-Mi Go; Jan Pohl; Matthew Reed; Jiyang Cai; Dean P Jones
Journal:  Chem Res Toxicol       Date:  2008-05-01       Impact factor: 3.739

7.  Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.

Authors:  Naoko Hanawa; Mie Shinohara; Behnam Saberi; William A Gaarde; Derick Han; Neil Kaplowitz
Journal:  J Biol Chem       Date:  2008-03-12       Impact factor: 5.157

8.  Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury.

Authors:  Yie Hou Lee; Maxey C M Chung; Qingsong Lin; Urs A Boelsterli
Journal:  Toxicol Appl Pharmacol       Date:  2008-04-12       Impact factor: 4.219

9.  Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition.

Authors:  Min He; Jiyang Cai; Young-Mi Go; Jennifer M Johnson; W David Martin; Jason M Hansen; Dean P Jones
Journal:  Toxicol Sci       Date:  2008-06-11       Impact factor: 4.849

Review 10.  Redox compartmentalization in eukaryotic cells.

Authors:  Young-Mi Go; Dean P Jones
Journal:  Biochim Biophys Acta       Date:  2008-01-26
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  23 in total

Review 1.  Molecular mechanisms underlying chemical liver injury.

Authors:  Xinsheng Gu; Jose E Manautou
Journal:  Expert Rev Mol Med       Date:  2012-02-03       Impact factor: 5.600

Review 2.  Mechanisms of drug toxicity and relevance to pharmaceutical development.

Authors:  F Peter Guengerich
Journal:  Drug Metab Pharmacokinet       Date:  2010-10-22       Impact factor: 3.614

3.  Profiling cumulative proportional reporting ratios of drug-induced liver injury in the FDA Adverse Event Reporting System (FAERS) database.

Authors:  Allen D Brinker; Jenna Lyndly; Joseph Tonning; David Moeny; Jonathan G Levine; Mark I Avigan
Journal:  Drug Saf       Date:  2013-12       Impact factor: 5.606

4.  The adaptive response (drug tolerance) helps to prevent drug-induced liver injury.

Authors:  James H Lewis
Journal:  Gastroenterol Hepatol (N Y)       Date:  2012-05

5.  Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.

Authors:  Jun Li; Fakhri Mahdi; Lin Du; Mika B Jekabsons; Yu-Dong Zhou; Dale G Nagle
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

6.  The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

Authors:  Mitchell R McGill; Matthew R Sharpe; C David Williams; Mohammad Taha; Steven C Curry; Hartmut Jaeschke
Journal:  J Clin Invest       Date:  2012-03-01       Impact factor: 14.808

7.  Role of bile acids in liver injury and regeneration following acetaminophen overdose.

Authors:  Bharat Bhushan; Prachi Borude; Genea Edwards; Chad Walesky; Joshua Cleveland; Feng Li; Xiaochao Ma; Udayan Apte
Journal:  Am J Pathol       Date:  2013-09-03       Impact factor: 4.307

8.  Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.

Authors:  Steven R McGreal; Bharat Bhushan; Chad Walesky; Mitchell R McGill; Margitta Lebofsky; Sylvie E Kandel; Robert D Winefield; Hartmut Jaeschke; Natasha E Zachara; Zhen Zhang; Ee Phie Tan; Chad Slawson; Udayan Apte
Journal:  Toxicol Sci       Date:  2018-04-01       Impact factor: 4.849

Review 9.  Drug-induced acute liver failure.

Authors:  William M Lee
Journal:  Clin Liver Dis       Date:  2013-09-04       Impact factor: 6.126

Review 10.  Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.

Authors:  Derick Han; Lily Dara; Sanda Win; Tin Aung Than; Liyun Yuan; Sadeea Q Abbasi; Zhang-Xu Liu; Neil Kaplowitz
Journal:  Trends Pharmacol Sci       Date:  2013-02-28       Impact factor: 14.819
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