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Literature DB >> 18549220

Organometallic activation of a fluorogen for templated nucleic acid detection.

Abstract

A nucleic acid detection scheme that employs DNA-mediated delivery of an organomercury activator to unmask a fluorophore is described. The approach relies on adjacent hybridization of two oligonucleotide conjugates containing organomercury and caged rhodamine functionalities. Postsynthetic conjugation of amino-modified DNAs enabled efficient preparation of these probes. Complementary DNA templates yielded fluorescence signals arising from metal-assisted rhodamine uncaging.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18549220 PMCID： PMC5508869 DOI： 10.1021/ol800878b

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

28 in total

1. Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations.

Authors: Y Xu; N B Karalkar; E T Kool
Journal: Nat Biotechnol Date: 2001-02 Impact factor: 54.908

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Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

Review 3. DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules.

Authors: Xiaoyu Li; David R Liu
Journal: Angew Chem Int Ed Engl Date: 2004-09-20 Impact factor: 15.336

4. Destabilizing universal linkers for signal amplification in self-ligating probes for RNA.

Authors: Hiroshi Abe; Eric T Kool
Journal: J Am Chem Soc Date: 2004-11-03 Impact factor: 15.419

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Journal: Biochem Biophys Res Commun Date: 1989-06-15 Impact factor: 3.575

6. In vivo monitoring of mercury ions using a rhodamine-based molecular probe.

Authors: Sung-Kyun Ko; Young-Keun Yang; Jinsung Tae; Injae Shin
Journal: J Am Chem Soc Date: 2006-11-01 Impact factor: 15.419

7. Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes.

Authors: Hiroshi Abe; Eric T Kool
Journal: Proc Natl Acad Sci U S A Date: 2005-12-29 Impact factor: 11.205

8. A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs.

Authors: Yanzheng Xu; Eric T Kool
Journal: Tetrahedron Lett Date: 1997-08-11 Impact factor: 2.415

9. New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA.

Authors: Gregory P Miller; Adam P Silverman; Eric T Kool
Journal: Bioorg Med Chem Date: 2007-05-03 Impact factor: 3.641

10. Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA.

Authors: Adam P Silverman; Eric T Kool
Journal: Nucleic Acids Res Date: 2005-09-02 Impact factor: 16.971

9 in total

1. Two successive reactions on a DNA template: a strategy for improving background fluorescence and specificity in nucleic acid detection.

Authors: Raphael M Franzini; Eric T Kool
Journal: Chemistry Date: 2011-01-10 Impact factor: 5.236

2. Templated chemistry for sequence-specific fluorogenic detection of duplex DNA.

Authors: Hao Li; Raphael M Franzini; Christopher Bruner; Eric T Kool
Journal: Chembiochem Date: 2010-10-18 Impact factor: 3.164

3. Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity.

Authors: Kosuke Ramon Ito; Tetsuya Kodama; Masaharu Tomizu; Yoshinori Negoro; Ayako Orita; Tomohisa Osaki; Noritsugu Hosoki; Takaya Tanaka; Takeshi Imanishi; Satoshi Obika
Journal: Nucleic Acids Res Date: 2010-07-08 Impact factor: 16.971

4. Efficient nucleic acid detection by templated reductive quencher release.

Authors: Raphael M Franzini; Eric T Kool
Journal: J Am Chem Soc Date: 2009-11-11 Impact factor: 15.419

5. 7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection.

Authors: Raphael M Franzini; Eric T Kool
Journal: Chembiochem Date: 2008-12-15 Impact factor: 3.164

6. Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity.

Authors: Dana Al Sulaiman; Jason Y H Chang; Sylvain Ladame
Journal: Angew Chem Int Ed Engl Date: 2017-04-06 Impact factor: 15.336

Review 7. Oligonucleotide-templated reactions for sensing nucleic acids.

Authors: Aya Shibata; Hiroshi Abe; Yoshihiro Ito
Journal: Molecules Date: 2012-02-29 Impact factor: 4.411

8. Cleavage of oligonucleotides containing a P3'→N5' phosphoramidate linkage mediated by single-stranded oligonucleotide templates.

Authors: Kosuke Ramon Ito; Tetsuya Kodama; Futaba Makimura; Noritsugu Hosoki; Tomohisa Osaki; Ayako Orita; Takeshi Imanishi; Satoshi Obika
Journal: Molecules Date: 2011-12-20 Impact factor: 4.411

9. Nucleic acid sensing by an orthogonal reporter system based on homo-DNA.

Authors: Matthias Stoop; Camille Désiron; Christian J Leumann
Journal: Artif DNA PNA XNA Date: 2013-01-01

9 in total