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Literature DB >> 18543973

Pyrrole-2-carboxylic acid as a ligand for the Cu-catalyzed reactions of primary anilines with aryl halides.

Ryan A Altman¹, Kevin W Anderson, Stephen L Buchwald.

Abstract

Pyrrole 2-carboxylic acid (L5) was found to be an effective ligand for the Cu-catalyzed monoarylation of anilines with aryl iodides and bromides. Under the reported conditions (10% CuI/20% L5/DMSO/K3PO 4/80-100 degrees C/20-24 h), a variety of useful functional groups were tolerated, and moderate to good yields of the diaryl amine products were obtained.

Entities: Chemical Gene

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Year: 2008 PMID： 18543973 PMCID： PMC2582381 DOI： 10.1021/jo8008676

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

17 in total

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Review 6. Biaryl phosphane ligands in palladium-catalyzed amination.

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9. An improved Cu-based catalyst system for the reactions of alcohols with aryl halides.

Authors: Ryan A Altman; Alexandr Shafir; Alice Choi; Phillip A Lichtor; Stephen L Buchwald
Journal: J Org Chem Date: 2007-11-29 Impact factor: 4.354

10. Room-temperature copper-catalyzed alpha-arylation of malonates.

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