Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Room-temperature copper-catalyzed alpha-arylation of malonates.

Literature DB >> 17637034

Room-temperature copper-catalyzed alpha-arylation of malonates.

Sau Fan Yip¹, Hong Yee Cheung, Zhongyuan Zhou, Fuk Yee Kwong.

Abstract

An effective method in targeting alpha-aryl malonates is reported. In the presence of a catalytic amount of 2-picolinic acid and CuI, the coupling of aryl iodides with diethyl malonate proceeds smoothly even at room temperature. The high levels of functional group compatibility and exceptionally mild reaction conditions offer this an attractive protocol in accessing a variety of arylated malonates.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17637034 DOI： 10.1021/ol701473p

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

Keyword Cloud
Cited

9 in total

1. Copper(I) enolate complexes in α-arylation reactions: synthesis, reactivity, and mechanism.

Authors: Zheng Huang; John F Hartwig
Journal: Angew Chem Int Ed Engl Date: 2011-12-08 Impact factor: 15.336

2. Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates.

Authors: Laxmidhar Rout; Sridhar Regati; Cong-Gui Zhao
Journal: Adv Synth Catal Date: 2011-12-06 Impact factor: 5.837

3. Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone.

Authors: Liming Cao; John P Maciejewski; Stephan Elzner; David Amantini; Peter Wipf
Journal: Org Biomol Chem Date: 2012-04-04 Impact factor: 3.876

4. Synthesis of Imidazo[1,2-f]phenanthridines by Recyclable Magnetic MOF-Catalyzed Coupling and Cyclization of 2-(2-Bromoaryl)imidazoles with Cyclohexane-1,3-diones Followed by Aromatization.

Authors: Seong Weon Lee; Pham Duy Quang Dao; Ho-Jin Lim; Chan Sik Cho
Journal: ACS Omega Date: 2022-05-24

Room-temperature copper-catalyzed alpha-arylation of malonates.

1. Copper(I) enolate complexes in α-arylation reactions: synthesis, reactivity, and mechanism.

2. Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates.

3. Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone.

4. Synthesis of Imidazo[1,2-f]phenanthridines by Recyclable Magnetic MOF-Catalyzed Coupling and Cyclization of 2-(2-Bromoaryl)imidazoles with Cyclohexane-1,3-diones Followed by Aromatization.

5. C-Arylation reactions catalyzed by CuO-nanoparticles under ligand free conditions.

6. Pyrrole-2-carboxylic acid as a ligand for the Cu-catalyzed reactions of primary anilines with aryl halides.

7. A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline.

8. A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.

9. Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of Ca_V1.3 Inhibitors.